Rabbit myosin IXB Polyclonal Antibody | anti-MYO9B antibody
Rabbit anti-human myosin IXB polyclonal Antibody
NCBI and Uniprot Product Information
Uniprot Description
MYO9B: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; Motor; Motility/polarity/chemotaxis; Actin-binding; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: ruffle; filamentous actin; filopodium tip; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; cell cortex; cytosol; myosin complex; actin cytoskeleton
Molecular Function: calmodulin binding; microfilament motor activity; actin filament binding; ATP-dependent protein binding; protein binding; protein homodimerization activity; zinc ion binding; ATPase activity; ADP binding; actin binding; actin-dependent ATPase activity; ATP binding
Biological Process: monocyte chemotaxis; regulation of small GTPase mediated signal transduction; ARF protein signal transduction; actin filament-based movement; establishment of cell polarity; metabolic process; small GTPase mediated signal transduction; macrophage chemotaxis
Disease: Celiac Disease, Susceptibility To, 4
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Product Notes
The myosin IXB myo9b (Catalog #AAA710844) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human myosin IXB polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's myosin IXB can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the myosin IXB myo9b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "myosin IXB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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