Rabbit anti-Human MYOM1 Polyclonal Antibody | anti-MYOM1 antibody

MYOM1 Antibody

Cat. Num. AAA9409103

• Gene Names: MYOM1; SKELEMIN
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: MYOM1; Polyclonal Antibody; MYOM1 Antibody; Myomesin-1; Myomesin family member 1; 190 kDa titin-associated protein; 190 kDa connectin-associated protein; anti-MYOM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MYOM1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 1685

• Applicable Applications for anti-MYOM1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50~1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human MYOM1.
• Target Name: MYOM1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using MYOM1 antibody.)

Related Product Information for anti-MYOM1 antibody

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.Hayess K., Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.Ota T., Nat. Genet. 36:40-45(2004).Nusbaum C., Nature 437:551-555(2005).

Product Categories/Family for anti-MYOM1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 140560919
• NCBI GeneID: 8736
• NCBI Accession #: NP_003794.3
• NCBI GenBank Nucleotide #: NM_003803.3
• UniProt Accession #: P52179; Q14BD6; Q6H969; Q6ZUU0
• Molecular Weight: 177,700 Da
• NCBI Official Full Name: myomesin-1 isoform a
• NCBI Official Synonym Full Names: myomesin 1
• NCBI Official Symbol: MYOM1
• NCBI Official Synonym Symbols: SKELEMIN
• NCBI Protein Information: myomesin-1
• UniProt Protein Name: Myomesin-1
• Protein Family: Myomesin
• UniProt Gene Name: MYOM1
• UniProt Entry Name: MYOM1_HUMAN

NCBI Description

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

myomesin 1: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 18p11.31

Cellular Component: striated muscle thick filament; M band

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; structural constituent of muscle

Biological Process: muscle contraction