Testing Data
Rabbit myocardin Polyclonal Antibody | anti-MYOCD antibody
myocardin Antibody
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Description
myocardin: Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: nucleus
Molecular Function: histone acetyltransferase binding; protein binding; histone deacetylase binding; transcription coactivator activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; regulation of cell growth by extracellular stimulus; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; uterus development; cardiac muscle cell differentiation; negative regulation of cell proliferation; regulation of smooth muscle cell differentiation; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; vasculogenesis; cardiac cell differentiation; positive regulation of DNA binding; urinary bladder development; positive regulation of smooth muscle cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cyclin-dependent protein kinase activity; regulation of histone acetylation; gut development; response to hypoxia; regulation of myoblast differentiation; positive regulation of transcription factor activity; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; alveolus development
Research Articles on MYOCD
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Product Notes
The MYOCD myocd (Catalog #AAA9410506) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's myocardin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the MYOCD myocd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "myocardin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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