Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7045365 at dilution of 1:100)
Rabbit anti-Human MYO5B Polyclonal Antibody | anti-MYO5B antibody
MYO5B Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7045365 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7045365 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045365 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045365 at dilution of 1:100)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Uniprot Description
MYO5B: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Defects in MYO5B are a cause of diarrhea type 2 (DIAR2). DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: apical cortex; cytoplasmic vesicle membrane; protein complex; recycling endosome
Molecular Function: microfilament motor activity; protein binding; Rab GTPase binding
Biological Process: endosome localization; renal water homeostasis; vesicle-mediated transport
Disease: Diarrhea 2, With Microvillus Atrophy
Research Articles on MYO5B
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Product Notes
The MYO5B myo5b (Catalog #AAA7045365) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MYO5B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MYO5B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC: 1:20-1:200. Researchers should empirically determine the suitability of the MYO5B myo5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MYO5B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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