Rabbit anti-Human MVP Polyclonal Antibody | anti-MVP antibody

MVP Polyclonal Antibody

Cat. Num. AAA3013083

• Gene Names: DDAH1; DDAH; DDAHI; DDAH-1; HEL-S-16
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: ProA affinity purified
• Synonyms: MVP; Polyclonal Antibody; MVP Polyclonal Antibody; DDAH-1; Dimethylarginine dimethylaminohydrolase 1; DDAH1; DDAH; LRP; Lung resistance related protein; Lung resistance-related protein; Major vault protein; rat; homolog of; testicular secretory protein Li 30; VAULT 1; VAULT1; anti-MVP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MVP polyclonal antibody detects endogenous levels of MVP protein.
• Purity/Purification: ProA affinity purified
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 182

• Applicable Applications for anti-MVP antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Application Notes: WB: 1:500-1:2,000; IHC: 1:50-1:200
• Immunogen: Recombinant protein
• Preparation and Storage: Store at 4 degree C after thawing.; Aliquot store at -20 degree C or -80 degree C.; Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of DDAH1 on human kidney (1) and human liver (2) tissue lysate using anti-DDAH1 antibody at 1/1,000 dilution.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-DDAH1 antibody. Counter stained with hematoxylin.)

Related Product Information for anti-MVP antibody

DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 197313763
• NCBI GeneID: 23576
• NCBI Accession #: NP_001127917.1
• NCBI GenBank Nucleotide #: NP_001127917.1
• UniProt Accession #: O94760
• NCBI Official Full Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 2
• NCBI Official Synonym Full Names: dimethylarginine dimethylaminohydrolase 1
• NCBI Official Symbol: DDAH1
• NCBI Official Synonym Symbols: DDAH; DDAHI; DDAH-1; HEL-S-16
• NCBI Protein Information: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
• UniProt Protein Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
• Protein Family: Hyperpolarization-activated voltage-gated potassium channel
• UniProt Gene Name: DDAH1
• UniProt Synonym Gene Names: DDAH; DDAH-1; Dimethylarginine dimethylaminohydrolase 1
• UniProt Entry Name: DDAH1_HUMAN

NCBI Description

This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

Uniprot Description

DDAH1: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Belongs to the DDAH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.3.18; Hydrolase

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: mitochondrion

Molecular Function: amino acid binding; dimethylargininase activity; metal ion binding; catalytic activity

Biological Process: positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; citrulline metabolic process; regulation of systemic arterial blood pressure; arginine catabolic process; nitric oxide mediated signal transduction