Rabbit anti-Human MT-ND3 Polyclonal Antibody | anti-MT-ND3 antibody

MT-ND3 Antibody

Cat. Num. AAA9410222

• Gene Names: MT-ND3; MTND3; ND3
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: MT-ND3; Polyclonal Antibody; MT-ND3 Antibody; MTND3; ND3; anti-MT-ND3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MT-ND3 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.5 mg/ml (varies by lot)
• Sequence Length: 115

• Applicable Applications for anti-MT-ND3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human mitochondrially encoded NADH dehydrogenase 3
• Target Name: MT-ND3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.)

Related Product Information for anti-MT-ND3 antibody

NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by trans-location of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 3 (ND3) localizes to the hydrophobic protein fragment of complex I. Mutations in the gene encodiing for ND3 may be associated with Parkinson disease.

Product Categories/Family for anti-MT-ND3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 251831114
• NCBI GeneID: 4537
• NCBI Accession #: YP_003024033.1
• NCBI GenBank Nucleotide #: NC_012920.1
• UniProt Accession #: P03897
• Molecular Weight: 13,186 Da
• NCBI Official Full Name: NADH dehydrogenase subunit 3 (mitochondrion)
• NCBI Official Synonym Full Names: mitochondrially encoded NADH dehydrogenase 3
• NCBI Official Symbol: MT-ND3
• NCBI Official Synonym Symbols: MTND3; ND3
• NCBI Protein Information: NADH dehydrogenase, subunit 3 (complex I)
• UniProt Protein Name: NADH-ubiquinone oxidoreductase chain 3
• UniProt Gene Name: MT-ND3
• UniProt Synonym Gene Names: MTND3; NADH3; ND3
• UniProt Entry Name: NU3M_HUMAN

Uniprot Description

MT-ND3: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND3 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in MT-ND3 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I subunit 3 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 1.6.5.3; Oxidoreductase; Energy Metabolism - oxidative phosphorylation; Mitochondrial

Chromosomal Location of Human Ortholog: -