Rabbit MPZL1 Polyclonal Antibody | anti-MPZL1 antibody

MPZL1 Polyclonal Antibody

Cat. Num. AAA2562714

• Gene Names: MPZL1; PZR; PZRa; PZRb; PZR1b; MPZL1b
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: MPZL1; Polyclonal Antibody; MPZL1 Polyclonal Antibody; immunoglobulin family transmembrane protein; MPZL1b; Myelin protein zero like 1; Myelin protein zero like protein 1; Myelin protein zero like protein 1 precursor; Myelin protein zero like protein MPZL1b; OTTHUMP00000032519; Protein zero related; PZR; PZR1b; PZRa; PZRb; anti-MPZL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.84mg/mL (varies by lot)
• Sequence Length: 119

• Applicable Applications for anti-MPZL1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human MPZL1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using MPZL1 Polyclonal Antibody at dilution of 1:30(×200))

Related Product Information for anti-MPZL1 antibody

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Product Categories/Family for anti-MPZL1 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 226054871
• NCBI GeneID: 9019
• NCBI Accession #: NP_001139663.1; BC007881
• NCBI GenBank Nucleotide #: NP_001139663.1
• UniProt Accession #: O95297
• NCBI Official Full Name: myelin protein zero-like protein 1 isoform c
• NCBI Official Synonym Full Names: myelin protein zero like 1
• NCBI Official Symbol: MPZL1
• NCBI Official Synonym Symbols: PZR; PZRa; PZRb; PZR1b; MPZL1b
• NCBI Protein Information: myelin protein zero-like protein 1
• UniProt Protein Name: Myelin protein zero-like protein 1
• Protein Family: Myelin protein zero-like protein
• UniProt Gene Name: MPZL1
• UniProt Synonym Gene Names: PZR
• UniProt Entry Name: MPZL1_HUMAN

Uniprot Description

PZR: an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: focal adhesion; cell surface; integral to plasma membrane

Molecular Function: protein binding; structural molecule activity

Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway