Goat MOZ/KAT6A Polyclonal Antibody | anti-MYST3 antibody

Goat anti-MOZ/KAT6A Antibody

Cat. Num. AAA421758

• Gene Names: KAT6A; MOZ; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A
• Reactivity: Expected from sequence similarity: Human
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: MOZ/KAT6A; Polyclonal Antibody; Goat anti-MOZ/KAT6A Antibody; MYST3; MYST histone acetyltransferase (monocytic leukemia) 3; KAT6A; MGC167033; MOZ; RUNXBP2; ZNF220; Monocytic leukemia zinc finger protein; runt-related transcription factor binding protein 2; zinc finger protein 220; MYST3 antibody; MYST histone acetyltransferase (monocytic leukemia) 3 antibody; KAT6A antibody; MGC167033 antibody; MOZ antibody; RUNXBP2 antibody; ZNF220 antibody; Monocytic leukemia zinc finger protein antibody; runt-related transcription factor binding protein 2 antibody; zinc finger protein 220 antibody; anti-MYST3 antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: EKIKDKEETELD
• Sequence Length: 2004

• Applicable Applications for anti-MYST3 antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 16000.; Western Blot: Preliminary experiments in lysates of cell line U937 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
• Immunogen: Peptide with sequence C-EKIKDKEETELD, from the Internal region of the protein sequence according to NP_006757.2.
• Epitope: Internal region
• Note: Reported variants NP_001092882.1, NP_006757.2, NP_001092883.1 represent identical protein.
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 150378493
• NCBI GeneID: 7994
• NCBI Accession #: NP_006757.2
• NCBI GenBank Nucleotide #: NM_006766.4
• Molecular Weight: 225,028 Da
• NCBI Official Full Name: histone acetyltransferase KAT6A isoform 1
• NCBI Official Synonym Full Names: lysine acetyltransferase 6A
• NCBI Official Symbol: KAT6A
• NCBI Official Synonym Symbols: MOZ; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A
• NCBI Protein Information: histone acetyltransferase KAT6A
• UniProt Protein Name: Histone acetyltransferase KAT6A
• UniProt Gene Name: KAT6A
• UniProt Synonym Gene Names: MOZ; MYST3; RUNXBP2; ZNF220; MYST-3
• UniProt Entry Name: KAT6A_HUMAN

NCBI Description

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

MYST3: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. Belongs to the MYST (SAS/MOZ) family.

Protein type: EC 2.3.1.48; Acetyltransferase; Oncoprotein; Nucleolus

Chromosomal Location of Human Ortholog: 8p11

Cellular Component: Golgi apparatus; nucleolus; nucleoplasm; nucleosome; nucleus; PML body

Molecular Function: acetyltransferase activity; DNA binding; histone acetyltransferase activity; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding

Biological Process: DNA packaging; histone acetylation; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; nucleosome assembly; positive regulation of transcription, DNA-dependent; protein amino acid acetylation; transcription, DNA-dependent

Disease: Mental Retardation, Autosomal Dominant 32