Western Blot (WB)
(Western blot analysis of lysates from mouse spleen tissue lysate, using MOUSE Bcar3 Antibody (C-term). MBS9207165 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.)
Rabbit MOUSE Bcar3 Polyclonal Antibody | anti-Bcar3 antibody
MOUSE Bcar3 Antibody (C-term)
Western Blot (WB)
(Western blot analysis of lysates from mouse spleen tissue lysate, using MOUSE Bcar3 Antibody (C-term). MBS9207165 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.)
Western Blot (WB)
(Western blot analysis of lysates from mouse spleen tissue lysate, using MOUSE Bcar3 Antibody (C-term). MBS9207165 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.)
Carninci P.,et al.Science 309:1559-1563(2005).
Gotoh T.,et al.J. Biol. Chem. 275:30118-30123(2000).
Cai D.,et al.J. Immunol. 170:969-978(2003).
NCBI and Uniprot Product Information
Uniprot Description
BCAR3: a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described.
Protein type: Adaptor/scaffold; GEFs, Ras; GEFs; Motility/polarity/chemotaxis
Molecular Function: guanyl-nucleotide exchange factor activity
Biological Process: small GTPase mediated signal transduction; lens morphogenesis in camera-type eye; signal transduction; positive regulation of peptidyl-serine phosphorylation
Research Articles on Bcar3
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Product Notes
The Bcar3 bcar3 (Catalog #AAA9207165) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MOUSE Bcar3 Antibody (C-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MOUSE Bcar3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Bcar3 bcar3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MOUSE Bcar3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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