Western Blot (WB)
(MOCS2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MOCS2 antibody detected the MOCS2 protein (arrow).)
Rabbit anti-Human MOCS2 Polyclonal Antibody | anti-MOCS2 antibody
MOCS2 Antibody (N-term)
Western Blot (WB)
(MOCS2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MOCS2 antibody detected the MOCS2 protein (arrow).)
Western Blot (WB)
(MOCS2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MOCS2 antibody detected the MOCS2 protein (arrow).)
(MoCo) consisting of a pterin, termed molybdopterin, and the
catalytically active metal molybdenum. MoCo is synthesized from
precursor Z by the heterodimeric enzyme molybdopterin synthase. The
large and small subunits of molybdopterin synthase are both encoded
from this gene by overlapping open reading frames. The proteins
were initially thought to be encoded from a bicistronic transcript.
They are now thought to be encoded from monocistronic transcripts.
Alternatively spliced transcripts have been found for this locus
that encode the large and small subunits.
Hahnewald, R., et al. Mol. Genet. Metab. 89(3):210-213(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Leimkuhler, S., et al. Hum. Genet. 117(6):565-570(2005)
Matthies, A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(16):5946-5951(2004)
NCBI and Uniprot Product Information
NCBI Description
Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]
Uniprot Description
MOCS2: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Defects in MOCS2 are the cause of molybdenum cofactor deficiency type B (MOCOD type B). MOCOD type B is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Belongs to the MoaE family. MOCS2B subfamily.
Protein type: Enzyme, misc.; EC 2.8.1.12
Chromosomal Location of Human Ortholog: 5q11
Cellular Component: molybdopterin synthase complex; cytoplasm; nucleus; cytosol
Molecular Function: identical protein binding; nucleotide binding; Mo-molybdopterin synthase activity
Biological Process: vitamin metabolic process; Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process; water-soluble vitamin metabolic process
Disease: Molybdenum Cofactor Deficiency, Complementation Group B
Research Articles on MOCS2
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Product Notes
The MOCS2 mocs2 (Catalog #AAA9212381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 14-43. The MOCS2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MOCS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MOCS2 mocs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MOCS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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