Western Blot (WB)
(Anti- ZEB2antibody, MBS177500, Western blottingAll lanes: Anti ZEB2 (MBS177500) at 0.5ug/mlWB: Recombinant Human ZEB2 Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD )
Rabbit Zinc finger E-box-binding homeobox 2 Polyclonal Antibody | anti-ZEB2 antibody
Anti-ZEB2 Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Western Blot (WB)
(Anti- ZEB2antibody, MBS177500, Western blottingAll lanes: Anti ZEB2 (MBS177500) at 0.5ug/mlWB: Recombinant Human ZEB2 Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD )
Western Blot (WB)
(Anti- ZEB2antibody, MBS177500, Western blottingAll lanes: Anti ZEB2 (MBS177500) at 0.5ug/mlWB: Recombinant Human ZEB2 Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD )
Western Blot (WB)
(Anti- ZEB2antibody, MBS177500, Western blottingAll lanes: Anti ZEB2 (MBS177500) at 0.5ug/mlWB: SMMC Whole Cell Lysate at 40ugPredicted bind size: 136KDObserved bind size: 136KD )
Western Blot (WB)
(Anti- ZEB2antibody, MBS177500, Western blottingAll lanes: Anti ZEB2 (MBS177500) at 0.5ug/mlWB: SMMC Whole Cell Lysate at 40ugPredicted bind size: 136KDObserved bind size: 136KD )
Background: ZEB2(Zinc finger E-box-binding homeobox2), also known as SIP1 or ZINC FINGER HOMEOBOX 1B(ZFHX1B), is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs, the transducers of TGF-beta signaling, and interacts with the nucleosome remodeling and histone deacetylation(NURD) complex. By radiation hybrid analysis, this gene is mapped to 2q22. It has been found that synthesis of ZEB2 was upregulated following SNAI1 expression in human cell lines, and the expression of SNAI1 in epithelial cells can trigger an epithelial-mesenchyme transition.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Description
ZEB2: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS); also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q22.3
Cellular Component: nucleus
Molecular Function: DNA binding; phosphatase regulator activity; metal ion binding
Biological Process: nervous system development; positive regulation of JNK activity; somitogenesis; transcription, DNA-dependent; cell proliferation in forebrain; pigmentation during development; hippocampus development; positive regulation of melanin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of melanocyte differentiation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; neural crest cell migration; positive regulation of Wnt receptor signaling pathway
Disease: Mowat-wilson Syndrome
Research Articles on ZEB2
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Product Notes
The ZEB2 zeb2 (Catalog #AAA177500) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ZEB2 Antibody reacts with Human. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Zinc finger E-box-binding homeobox 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human. Researchers should empirically determine the suitability of the ZEB2 zeb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Zinc finger E-box-binding homeobox 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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