Rabbit anti-Human MOAP1 Polyclonal Antibody | anti-MOAP1 antibody

MOAP1, NT (MOAP1, PNMA4, Modulator of apoptosis 1, Paraneoplastic antigen Ma4) (Azide free) (HRP)

Cat. Num. AAA6321563

• Gene Names: MOAP1; MAP-1; PNMA4
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: MOAP1; Polyclonal Antibody; NT (MOAP1; PNMA4; Modulator of apoptosis 1; Paraneoplastic antigen Ma4) (Azide free) (HRP); Paraneoplastic antigen Ma4; anti-MOAP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MOAP1.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-MOAP1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 37-65 in the N-terminal region of human MOAP1, UniProt Accession #Q96BY2. Species sequence homology: monkey
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in 293 cell line lysates (35ug/lane) usingMBS6012495. This demonstrates MBS6012495 detected the MOAP1 protein (arrow).)

Related Product Information for anti-MOAP1 antibody

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.

Product Categories/Family for anti-MOAP1 antibody

Antibodies; Apoptosis

References

Lee, S.S., et al. Exp. Cell Res. 315(7):1313-1325(2009)Foley, C.J., et al. Mol. Cell. Biol. 28(14):4520-4535(2008). Fu, N.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(24):10051-10056(2007). Lim, J., et al. Cell 125(4):801-814(2006). Vos, M.D., et al. J. Biol. Chem. 281(8):4557-4563(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 19923584
• NCBI GeneID: 64112
• NCBI Accession #: NP_071434.2
• NCBI GenBank Nucleotide #: NM_022151.4
• UniProt Accession #: Q96BY2; Q9H833; Q9HAS1; B2RDF6
• Molecular Weight: 39,513 Da
• NCBI Official Full Name: modulator of apoptosis 1
• NCBI Official Synonym Full Names: modulator of apoptosis 1
• NCBI Official Symbol: MOAP1
• NCBI Official Synonym Symbols: MAP-1; PNMA4
• NCBI Protein Information: modulator of apoptosis 1; MAP1; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen like 4
• UniProt Protein Name: Modulator of apoptosis 1
• Protein Family: Modulator of apoptosis
• UniProt Gene Name: MOAP1
• UniProt Synonym Gene Names: PNMA4; MAP-1; MAP1
• UniProt Entry Name: MOAP1_HUMAN

NCBI Description

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family.

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; protein insertion into mitochondrial membrane during induction of apoptosis; positive regulation of apoptosis