Western Blot (WB)
(Western blot analysis of MNDA Antibody (N-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in CEM cell line lysate. MNDA Antibody (N-term) (arrow) was detected using the purified Pab.)
Rabbit anti-Human MNDA Polyclonal Antibody | anti-MNDA antibody
MNDA Antibody (N-term)
Western Blot (WB)
(Western blot analysis of MNDA Antibody (N-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in CEM cell line lysate. MNDA Antibody (N-term) (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of MNDA Antibody (N-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in CEM cell line lysate. MNDA Antibody (N-term) (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(MNDA Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MNDA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(MNDA Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MNDA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(MNDA Antibody (N-term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(MNDA Antibody (N-term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
detected only in nuclei of cells of the granulocyte-monocyte
lineage. A 200-amino acid region of human MNDA is strikingly
similar to a region in the proteins encoded by a family of
interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and
Ifi-203, that are not regulated in a cell- or tissue-specific
fashion. The 1.8-kb MNDA mRNA, which contains an
interferon-stimulated response element in the 5-prime untranslated
region, was significantly upregulated in human monocytes exposed to
interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS,
CRP, and SPTA1. In its pattern of expression and/or regulation,
MNDA resembles IFI16, suggesting that these genes participate in
blood cell-specific responses to interferons.
Kanellis, G., et al. Leukemia 23(10):1847-1857(2009)
Joshi, A.D., et al. Clin. Cancer Res. 13 (18 PT 1), 5295-5304 (2007) :
Briggs, R.C., et al. Cancer Res. 66(9):4645-4651(2006)
Asefa, B., et al. FEBS Lett. 580(5):1205-1214(2006)
NCBI and Uniprot Product Information
NCBI Description
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
Uniprot Description
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Research Articles on MNDA
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Product Notes
The MNDA mnda (Catalog #AAA9207672) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-53. The MNDA Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MNDA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the MNDA mnda for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MNDA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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