Western Blot (WB)
(Western blot analysis of lysates from HLVEC, HUVEC cell line (from left to right), using MMRN1 Antibody (N-term). MBS9212688 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
Rabbit anti-Human MMRN1 Polyclonal Antibody | anti-MMRN1 antibody
MMRN1 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of lysates from HLVEC, HUVEC cell line (from left to right), using MMRN1 Antibody (N-term). MBS9212688 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
Western Blot (WB)
(Western blot analysis of lysates from HLVEC, HUVEC cell line (from left to right), using MMRN1 Antibody (N-term). MBS9212688 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
platelets and in the endothelium of blood vessels. It is comprised
of subunits linked by interchain disulfide bonds to form large,
variably sized homomultimers. Multimerin is a factor V/Va-binding
protein and may function as a carrier protein for platelet factor
V. It may also have functions as an extracellular matrix or
adhesive protein. Recently, patients with an unusual
autosomal-dominant bleeding disorder (factor V Quebec) were found
to have a deficiency of platelet multimerin.
Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)
Tasneem, S., et al. J. Thromb. Haemost. 7(4):685-692(2009)
Jeimy, S.B., et al. Thromb. Haemost. 100(6):1058-1067(2008)
Jeimy, S.B., et al. Thromb. Res. 123(2):352-354(2008)
NCBI and Uniprot Product Information
NCBI Description
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq, Jul 2008]
Uniprot Description
MMRN1: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: extracellular region
Biological Process: platelet activation; platelet degranulation; blood coagulation; cell adhesion
Research Articles on MMRN1
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Product Notes
The MMRN1 mmrn1 (Catalog #AAA9212688) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 179-207. The MMRN1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MMRN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MMRN1 mmrn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMRN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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