Rabbit anti-Human MMRN1 Polyclonal Antibody | anti-MMRN1 antibody

MMRN1, NT (MMRN1, ECM, EMILIN4, GPIA*, MMRN, Multimerin-1, EMILIN-4, Elastin microfibril interface located protein 4, Endothelial cell multimerin, Platelet glycoprotein Ia*, 155kD platelet multimerin) (MaxLight 750)

Cat. Num. AAA6321491

• Gene Names: MMRN1; ECM; MMRN; GPIa*; EMILIN4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: MMRN1; Polyclonal Antibody; NT (MMRN1; ECM; EMILIN4; GPIA*; MMRN; Multimerin-1; EMILIN-4; Elastin microfibril interface located protein 4; Endothelial cell multimerin; Platelet glycoprotein Ia*; 155kD platelet multimerin) (MaxLight 750); 155kD platelet multimerin; anti-MMRN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MMRN1.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-MMRN1 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 179-207 in the N-terminal region of human MMRN1.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in WiDr cell line lysates (35ug/lane), usingMBS6012223. This demonstrates that MBS6012223 detected the MMRN1 protein (arrow).)

Related Product Information for anti-MMRN1 antibody

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.

Product Categories/Family for anti-MMRN1 antibody

Antibodies; Elastin

References

1. Davila, S., et al. Genes Immun. 11(3):232-238(2010). 2. Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009). 3. Tasneem, S., et al. J. Thromb. Haemost. 7(4):685-692(2009). 4. Jeimy, S.B., et al. Thromb. Haemost. 100(6):1058-1067(2008). 5. Jeimy, S.B., et al. Thromb. Res. 123(2):352-354(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 45269141
• NCBI GeneID: 22915
• NCBI Accession #: NP_031377.2
• NCBI GenBank Nucleotide #: NM_007351.2
• UniProt Accession #: Q13201; Q4W5L1; Q6P3T8; Q6ZUL9
• Molecular Weight: 58,170 Da
• NCBI Official Full Name: multimerin-1
• NCBI Official Synonym Full Names: multimerin 1
• NCBI Official Symbol: MMRN1
• NCBI Official Synonym Symbols: ECM; MMRN; GPIa*; EMILIN4
• NCBI Protein Information: multimerin-1
• UniProt Protein Name: Multimerin-1
• Protein Family: Multimerin
• UniProt Gene Name: MMRN1
• UniProt Synonym Gene Names: ECM; EMILIN4; GPIA*; MMRN; Elastin microfibril interfacer 4; p-155; p155

NCBI Description

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq, Jul 2008]

Uniprot Description

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.