Flow Cytometry (FC/FACS)
Mouse anti-Human IRS1 Monoclonal Antibody | anti-IRS1 antibody
Anti-Human IRS1 DyLight 488 Conjugated Antibody (Monoclonal, 10I3)
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Flow Cytometry (FC/FACS)
Flow Cytometry (FC/FACS)
Flow Cytometry (FC/FACS)
Flow Cytometry (FC/FACS)
Background: Insulin receptor substrate 1(IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1(IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. IRS1 also has important biological function for both metabolic and mitogenic(growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.
2. Houghton, A. M., Rzymkiewicz, D. M., Ji, H., Gregory, A. D., Egea, E. E., Metz, H. E., Stolz, D. B., Land, S. R., Marconcini, L. A., Kliment, C. R., Jenkins, K. M., Beaulieu, K. A., Mouded, M., Frank, S. J., Wong, K. K., Shapiro, S. D. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature Med. 16: 219-223, 2010.
NCBI and Uniprot Product Information
Uniprot Description
IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; intracellular; nucleus; cytosol
Molecular Function: insulin-like growth factor receptor binding; protein domain specific binding; protein binding; signal transducer activity; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; protein kinase binding; insulin receptor binding
Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; protein heterooligomerization; positive regulation of glycogen biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; negative regulation of insulin receptor signaling pathway; signal transduction; positive regulation of fatty acid beta-oxidation; negative regulation of insulin secretion; response to caffeine; response to insulin stimulus; positive regulation of glucose import; insulin-like growth factor receptor signaling pathway; mammary gland development; cellular response to insulin stimulus; regulation of gene expression; insulin secretion; positive regulation of mesenchymal cell proliferation; protein kinase B signaling cascade; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of phosphorylation; lipid catabolic process; positive regulation of cell migration
Research Articles on IRS1
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Product Notes
The IRS1 irs1 (Catalog #AAA1753196) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human IRS1 DyLight 488 Conjugated Antibody (Monoclonal, 10I3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IRS1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). FC/FACS: 1-3ug/1x106 cells (Human). Researchers should empirically determine the suitability of the IRS1 irs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRS1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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