Rabbit MMP11 Polyclonal Antibody | anti-MMP11 antibody

MMP11 antibody

Cat. Num. AAA9409414

• Gene Names: MMP11; ST3; SL-3; STMY3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: MMP11; Polyclonal Antibody; MMP11 antibody; ST3; SL-3; STMY3; anti-MMP11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total MMP11 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 488

• Applicable Applications for anti-MMP11 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human MMP11.
• SDS-PAGE MW: 55kD
• Target Name: MMP11
• Preparation and Storage: Store at -20°C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using MMP11 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lung cancer tissue using MMP11 antibody.)

Related Product Information for anti-MMP11 antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Product Categories/Family for anti-MMP11 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 58331148
• NCBI GeneID: 4320
• NCBI Accession #: NP_005931.2
• NCBI GenBank Nucleotide #: NM_005940.3
• UniProt Accession #: P24347; Q5FX24; Q6PEZ6; Q9UC26
• NCBI Official Full Name: stromelysin-3 preproprotein
• NCBI Official Synonym Full Names: matrix metallopeptidase 11
• NCBI Official Symbol: MMP11
• NCBI Official Synonym Symbols: ST3; SL-3; STMY3
• NCBI Protein Information: stromelysin-3
• UniProt Protein Name: Stromelysin-3
• Protein Family: Stromelysin
• UniProt Gene Name: MMP11
• UniProt Synonym Gene Names: STMY3; SL-3; ST3; MMP-11
• UniProt Entry Name: MMP11_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

Uniprot Description

MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.-; Secreted, signal peptide; Secreted; Extracellular matrix; Protease

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: proteinaceous extracellular matrix; Golgi lumen; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; negative regulation of fat cell differentiation; proteolysis