Immunohistochemistry (IHC)
(Immunochemical staining of human MMP15 in human adrenal gland with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human MMP-15/MT2-MMP Polyclonal Antibody | anti-MMP15 antibody
Anti-MMP-15/MT2-MMP Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
MMP-15/MT2-MMP; Polyclonal Antibody; Anti-MMP-15/MT2-MMP Antibody; Rabbit Polyclonal; MMP-15 Antibody; Rabbit PAb; Antigen Affinity Purified; matrix metallopeptidase 15 (membrane-inserted); Anti-MT2-MMP Antibody; Anti-MTMMP2 Antibody; Anti-SMCP-2 Antibody; anti-MMP15 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human MMP-15
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-MMP15 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:100-1:500
Immunogen
E Coli-derived Human MMP-15 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human MMP-15 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human MMP15 in human adrenal gland with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MMP15 in human adrenal gland with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MMP15 in human breast with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MMP15 in human breast with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-MMP15 antibody
Membrane-type 2 matrix metalloproteinase (MT2-MMP; also known as MMP15) is a membrane-bound protease that degrades extracellular matrix and activates ProMMPs such as ProMMP-2. MMP15 is the membrane-type MMP (MT-MMP) which is a recently identified matrix metalloproteinase (MMP) capable of degrading all kinds of extracellular matrix proteins as well as numerous bioactive molecules. Matrix metalloproteinase 15 (MMP15) is the functional regulated gene of miR-339-5p in breast carcinoma. The MMP15 was identified to be a target of miR-339-5p. The level of MMP15 was negatively regulated by miR-339-5p whereas positively controlled by MAFG-AS1. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. MMP7 and MMP15 were overexpressed in acute myeloid leukemia (AML) patients.
References
Patterson RA, et al. (2013) Mt2-mmp expression during early avian morphogenesis. Anat Rec (Hoboken) 296 (1): 64-70.Li H, et al. (2019) Lncrna mafg-as1 promotes the aggressiveness of breast carcinoma through regulating mir-339-5p/mmp15. Eur Rev Med Pharmacol Sci 23 (7): 2838-2846.Kim OH, et al. (2019) Generation of mmp15b zebrafish mutant to investigate liver diseases. Dev Reprod 23 (4): 385-390.Jia YC, et al. (2019) Lncrna mafg-as1 facilitates the migration and invasion of nsclc cell via sponging mir-339-5p from mmp15. Cell Biol Int 43 (4): 384-393.
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Product Notes
The MMP15 (Catalog #AAA8107860) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MMP-15/MT2-MMP Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MMP-15/MT2-MMP can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:100-1:500. Researchers should empirically determine the suitability of the MMP15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMP-15/MT2-MMP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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