Western Blot (WB)
(Western blot analysis of MMAA Antibody (N-term) in mouse liver tissue lysates (35ug/lane). MMAA (arrow) was detected using the purified Pab.)
Rabbit anti-Human, Mouse MMAA Polyclonal Antibody | anti-MMAA antibody
MMAA, NT (MMAA, Methylmalonic aciduria type A protein, mitochondrial)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Western Blot (WB)
(Western blot analysis of MMAA Antibody (N-term) in mouse liver tissue lysates (35ug/lane). MMAA (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of MMAA Antibody (N-term) in mouse liver tissue lysates (35ug/lane). MMAA (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(MMAA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human skeletal muscle tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.)
Immunohistochemistry (IHC)
(MMAA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human skeletal muscle tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Uniprot Description
MMAA: Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Defects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA); also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive. Belongs to the ArgK family.
Protein type: Chaperone; EC 3.6.-.-
Chromosomal Location of Human Ortholog: 4q31.21
Cellular Component: mitochondrial matrix
Molecular Function: GTP binding; hydrolase activity
Biological Process: vitamin metabolic process; fatty acid beta-oxidation; cobalamin biosynthetic process; short-chain fatty acid catabolic process; cobalamin metabolic process; cellular lipid metabolic process; water-soluble vitamin metabolic process
Disease: Methylmalonic Aciduria, Cbla Type
Research Articles on MMAA
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Product Notes
The MMAA mmaa (Catalog #AAA6003775) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MMAA, NT (MMAA, Methylmalonic aciduria type A protein, mitochondrial) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MMAA can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot, Immunohistochemistry Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100. Researchers should empirically determine the suitability of the MMAA mmaa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMAA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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