Rabbit anti-Human MLXIPL Polyclonal Antibody | anti-MLXIPL antibody

MLXIPL, CT (MLXIPL, BHLHD14, MIO, WBSCR14, Carbohydrate-responsive element-binding protein, Class D basic helix-loop-helix protein 14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, Williams-Beuren syndrome

Cat. Num. AAA6321228

• Gene Names: MLXIPL; MIO; MLX; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MLXIPL; Polyclonal Antibody; CT (MLXIPL; BHLHD14; MIO; WBSCR14; Carbohydrate-responsive element-binding protein; Class D basic helix-loop-helix protein 14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein; Williams-Beuren syndrome; Williams-Beuren syndrome chromosomal region 14 protein; anti-MLXIPL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 850

• Applicable Applications for anti-MLXIPL antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 623-653 amino acids from the C-terminal region of human MLXIPL.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(MLXIPL Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLXIPL antibody detected the MLXIPL protein (arrow).)

Immunohistochemistry (IHC)

(MLXIPL Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-MLXIPL antibody

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.

Product Categories/Family for anti-MLXIPL antibody

Antibodies; Binding Proteins

References

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010). Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010). Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010). Chidambaram, M., et al. Metab. Clin. Exp. (2010). In press: Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 14602437
• NCBI GeneID: 51085
• NCBI Accession #: NP_116571.1; NP_116569.1
• NCBI GenBank Nucleotide #: NP_116571.1
• UniProt Accession #: Q9NP71
• NCBI Official Full Name: carbohydrate-responsive element-binding protein isoform gamma
• NCBI Official Synonym Full Names: MLX interacting protein like
• NCBI Official Symbol: MLXIPL
• NCBI Official Synonym Symbols: MIO; MLX; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
• NCBI Protein Information: carbohydrate-responsive element-binding protein
• UniProt Protein Name: Williams-Beuren syndrome chromosomal region 14 protein
• Protein Family: Carbohydrate-responsive element-binding protein
• UniProt Gene Name: MLXIPL
• UniProt Synonym Gene Names: BHLHD14; MIO; WBSCR14
• UniProt Entry Name: WBS14_HUMAN

NCBI Description

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]