Rabbit anti-Human MLXIPL Polyclonal Antibody | anti-MLXIPL antibody

MLXIPL, CT (MLXIPL, BHLHD14, MIO, WBSCR14, Carbohydrate-responsive element-binding protein, Class D basic helix-loop-helix protein 14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, Williams-Beuren syndrome

Cat. Num. AAA6321218

• Gene Names: MLXIPL; MIO; MLX; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MLXIPL; Polyclonal Antibody; CT (MLXIPL; BHLHD14; MIO; WBSCR14; Carbohydrate-responsive element-binding protein; Class D basic helix-loop-helix protein 14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein; Williams-Beuren syndrome; Williams-Beuren syndrome chromosomal region 14 protein; anti-MLXIPL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 850

• Applicable Applications for anti-MLXIPL antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 623-653 amino acids from the C-terminal region of human MLXIPL.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(MLXIPL Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLXIPL antibody detected the MLXIPL protein (arrow).)

Immunohistochemistry (IHC)

(MLXIPL Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-MLXIPL antibody

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.

Product Categories/Family for anti-MLXIPL antibody

Antibodies; Binding Proteins

References

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010). Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010). Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010). Chidambaram, M., et al. Metab. Clin. Exp. (2010). In press: Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 14602437
• NCBI GeneID: 51085
• NCBI Accession #: NP_116571.1; NP_116569.1
• NCBI GenBank Nucleotide #: NP_116571.1
• UniProt Accession #: Q9NP71
• NCBI Official Full Name: carbohydrate-responsive element-binding protein isoform gamma
• NCBI Official Synonym Full Names: MLX interacting protein like
• NCBI Official Symbol: MLXIPL
• NCBI Official Synonym Symbols: MIO; MLX; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
• NCBI Protein Information: carbohydrate-responsive element-binding protein
• UniProt Protein Name: Williams-Beuren syndrome chromosomal region 14 protein
• Protein Family: Carbohydrate-responsive element-binding protein
• UniProt Gene Name: MLXIPL
• UniProt Synonym Gene Names: BHLHD14; MIO; WBSCR14
• UniProt Entry Name: WBS14_HUMAN

NCBI Description

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]