Western Blot (WB)
((1ug/ml) staining of Rat Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat MLLT10/AF10 Polyclonal Antibody | anti-MLLT10 antibody
Goat anti-MLLT10/AF10 Antibody
Western Blot: Experiments gave bands at approx 140kDa and 60kDa in Rat Testis lysates. These bands correspond to earlier findings with different antibodies from other commercial sources. This protein has a calculated MW of 109kDa according to Human NP_004632.1, 107kDa according to Human NP_001009569.1and 103kDa according to Rat NP_001012162.1. Recommended concentration: 1-3ug/ml.
Western Blot (WB)
((1ug/ml) staining of Rat Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((1ug/ml) staining of Rat Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Description
MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 10p12
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: DNA binding; protein binding; transcription factor activity; zinc ion binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Leukemia, Acute Myeloid
Research Articles on MLLT10
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Product Notes
The MLLT10 mllt10 (Catalog #AAA422353) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-MLLT10/AF10 Antibody reacts with Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's MLLT10/AF10 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Experiments gave bands at approx 140kDa and 60kDa in Rat Testis lysates. These bands correspond to earlier findings with different antibodies from other commercial sources. This protein has a calculated MW of 109kDa according to Human NP_004632.1, 107kDa according to Human NP_001009569.1and 103kDa according to Rat NP_001012162.1. Recommended concentration: 1-3ug/ml. Researchers should empirically determine the suitability of the MLLT10 mllt10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: RLEDTTARFT NAN. It is sometimes possible for the material contained within the vial of "MLLT10/AF10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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