Western Blot (WB)
(Western Blot analysis of NIH-3T3, cells using Phospho-MLK3 (S674) Polyclonal Antibody)
Rabbit MLK3 Polyclonal Antibody | anti-MLK3 antibody
MLK3 (Phospho-Ser674) Polyclonal Antibody
ELISA: 1:5000
Not yet tested in other applications
Western Blot (WB)
(Western Blot analysis of NIH-3T3, cells using Phospho-MLK3 (S674) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of NIH-3T3, cells using Phospho-MLK3 (S674) Polyclonal Antibody)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Uniprot Description
MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; EC 2.7.11.25; TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 11q13.1-q13.3
Cellular Component: centrosome; microtubule; membrane; cytoplasm
Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; protein homodimerization activity; JUN kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; protein-tyrosine kinase activity; Rac GTPase binding; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity
Biological Process: cell death; cell proliferation; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of neuron apoptosis; positive regulation of JNK cascade; JNK cascade; protein amino acid phosphorylation; activation of JNK activity; microtubule-based process; activation of JNKK activity
Research Articles on MLK3
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Product Notes
The MLK3 map3k11 (Catalog #AAA9407350) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MLK3 (Phospho-Ser674) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MLK3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Western blotting: 1:500 - 1:2000 ELISA: 1:5000 Not yet tested in other applications. Researchers should empirically determine the suitability of the MLK3 map3k11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLK3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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