Rabbit anti-Human SFRS17A Polyclonal Antibody | anti-SFRS17A antibody

SFRS17A, ID (AKAP17A, CXYorf3, DXYS155E, SFRS17A, XE7, A-kinase anchor protein 17A, 721P, B-lymphocyte antigen, Protein XE7, Protein kinase A-anchoring protein 17A, Splicing factor, arginine/serine-rich 17A) (APC)

Cat. Num. AAA6346670

• Gene Names: AKAP17A; XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SFRS17A; Polyclonal Antibody; ID (AKAP17A; CXYorf3; DXYS155E; XE7; A-kinase anchor protein 17A; 721P; B-lymphocyte antigen; Protein XE7; Protein kinase A-anchoring protein 17A; Splicing factor; arginine/serine-rich 17A) (APC); AKAP17A; arginine/serine-rich 17A; anti-SFRS17A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-SFRS17A antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SFRS17A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-343 amino acids from the Central region of human SFRS17A.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SFRS17A Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the SFRS17A antibody detected the SFRS17A protein (arrow).)

Related Product Information for anti-SFRS17A antibody

This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.

Product Categories/Family for anti-SFRS17A antibody

Antibodies; Splicing Factors

References

Jarnaess, E., et al. J. Biol. Chem. 284(50):35154-35164(2009). Mangs, A.H., et al. Nucleic Acids Res. 34(17):4976-4986(2006). Ried, K., et al. Hum. Mol. Genet. 7(11):1771-1778(1998). Ellison, J.W., et al. Hum. Mol. Genet. 1(9):691-696(1992) Voland, J.R., et al. Proc. Natl. Acad. Sci. U.S.A. 89(21):10425-10429(1992).

NCBI and Uniprot Product Information

• NCBI GI #: 41152097
• NCBI GeneID: 8227
• NCBI Accession #: NP_005079.2
• NCBI GenBank Nucleotide #: NM_005088.2
• UniProt Accession #: Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9
• Molecular Weight: 80,735 Da
• NCBI Official Full Name: A-kinase anchor protein 17A isoform 1
• NCBI Official Synonym Full Names: A kinase (PRKA) anchor protein 17A
• NCBI Official Symbol: AKAP17A
• NCBI Official Synonym Symbols: XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E
• NCBI Protein Information: A-kinase anchor protein 17A; pseudoautosomal gene XE7; B-lymphocyte surface antigen; protein kinase A-anchoring protein 17A; splicing factor, arginine/serine-rich 17A
• UniProt Protein Name: A-kinase anchor protein 17A
• UniProt Gene Name: AKAP17A
• UniProt Synonym Gene Names: CXYorf3; DXYS155E; SFRS17A; XE7; AKAP-17A; PRKA17A
• UniProt Entry Name: AK17A_HUMAN

NCBI Description

This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]

Uniprot Description

SFRS17A: Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.32

Cellular Component: nucleoplasm; spliceosome; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; protein kinase A binding; nucleotide binding

Biological Process: B cell activation; regulation of transcription, DNA-dependent; regulation of RNA splicing; RNA splicing; signal transduction; mRNA processing