Rabbit anti-Human, Rat MKI67 / Ki67 Polyclonal Antibody | anti-MKI67 antibody

Rabbit Polyclonal (IgG) to Human MKI67 / Ki67

Cat. Num. AAA244383

• Gene Names: MKI67; KIA; MIB-; MIB-1; PPP1R105
• Reactivity: Human, Rat
• Applications: Immunohistochemistry
• Purity: Protein A Purified
• Synonyms: MKI67 / Ki67; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human MKI67 / Ki67; Anti-MKI67 / Ki67 Antibody (Internal) IHC-plus; MKI67; Antigen KI-67; Ki67; KIA; Human MKI67; anti-MKI67 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: middle of Ki67 protein
• Purity/Purification: Protein A Purified
• Form/Format: 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 3256

• Applicable Applications for anti-MKI67 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: A synthetic peptide from the human Ki67 protein.
• Immunogen Type: Synthetic peptide
• Immunogen: MKI67 / Ki67 antibody was raised against a synthetic peptide from the human Ki67 protein.
• Antigen Modification: Internal
• Preparation and Storage: Stable for 24 months when stored at 2-8 degree C.

Immunohistochemistry (IHC)

(Anti-MKI67 / Ki-67 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 103472005
• NCBI GeneID: 4288
• NCBI Accession #: NP_002408.3
• NCBI GenBank Nucleotide #: NM_002417.4
• UniProt Accession #: P46013; Q5VWH2
• Molecular Weight: 319,444 Da
• NCBI Official Full Name: antigen KI-67 isoform 1
• NCBI Official Synonym Full Names: marker of proliferation Ki-67
• NCBI Official Symbol: MKI67
• NCBI Official Synonym Symbols: KIA; MIB-; MIB-1; PPP1R105
• NCBI Protein Information: antigen KI-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; antigen identified by monoclonal antibody Ki-67
• UniProt Protein Name: Antigen KI-67
• Protein Family: Proliferation marker protein
• UniProt Gene Name: MKI67
• UniProt Entry Name: KI67_HUMAN

NCBI Description

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

Uniprot Description

KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: membrane; cytoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein binding; ATP binding

Biological Process: meiosis; cell proliferation