Rabbit MGST1 Polyclonal Antibody | anti-MGST1 antibody

MGST1 Polyclonal Antibody

Cat. Num. AAA2522865

• Gene Names: MGST1; MGST; GST12; MGST-I
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: MGST1; Polyclonal Antibody; MGST1 Polyclonal Antibody; MGST; GST12; MGST-I; anti-MGST1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.9mg/mL (varies by lot)
• Sequence Length: 87

• Applicable Applications for anti-MGST1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human MGST1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MGST1 Polyclonal Antibody at dilution 1:35)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using MGST1 Polyclonal Antibody at dilution 1:35)

Related Product Information for anti-MGST1 antibody

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.

NCBI and Uniprot Product Information

• NCBI GI #: 390125204
• NCBI GeneID: 4257
• NCBI Accession #: NP_001254527.1
• NCBI GenBank Nucleotide #: NM_001267598.1
• Molecular Weight: 9,984 Da
• NCBI Official Full Name: microsomal glutathione S-transferase 1 isoform c
• NCBI Official Synonym Full Names: microsomal glutathione S-transferase 1
• NCBI Official Symbol: MGST1
• NCBI Official Synonym Symbols: MGST; GST12; MGST-I
• NCBI Protein Information: microsomal glutathione S-transferase 1; glutathione S-transferase 12; microsomal GST-1; microsomal GST-I
• UniProt Protein Name: Microsomal glutathione S-transferase 1
• Protein Family: Microsomal glutathione S-transferase
• UniProt Gene Name: MGST1
• UniProt Synonym Gene Names: GST12; MGST; Microsomal GST-1
• UniProt Entry Name: MGST1_HUMAN

NCBI Description

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Description

MGST1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Belongs to the MAPEG family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Transferase; Mitochondrial; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18

Chromosomal Location of Human Ortholog: 12p12.3-p12.1

Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; apical part of cell; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; glutathione binding; glutathione transferase activity; glutathione peroxidase activity

Biological Process: response to drug; glutathione metabolic process; Leydig cell differentiation; xenobiotic metabolic process; response to lipopolysaccharide; response to organic nitrogen