Goat MFN1 Polyclonal Antibody | anti-MFN1 antibody

Goat Polyclonal to Human MFN1

Cat. Num. AAA244439

• Gene Names: MFN1; hfzo1; hfzo2
• Reactivity: Gibbon, Dog, Horse, Human, Monkey, Rabbit; Predicted Reactivity: Gorilla, Mouse, Rat, Bovine (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: MFN1; Polyclonal Antibody; Goat Polyclonal to Human MFN1; Anti-MFN1 Antibody IHC-plus; Fzo homolog; Hfzo2; Mitofusin-1; Hfzo1; Mitofusin 1; Putative transmembrane GTPase; Transmembrane GTPase MFN1; Human MFN1; anti-MFN1 antibody

• Host: Goat
• Reactivity: Gibbon, Dog, Horse, Human, Monkey, Rabbit; Predicted Reactivity: Gorilla, Mouse, Rat, Bovine (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human MFN1.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 741

• Applicable Applications for anti-MFN1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-NKAVQLENELEN from an internal region of human MFN1 (NP_284941.2). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Elephant, Dog, Horse, Rabbit (100%); Gorilla, Mouse, Rat, Bovine (92%).
• Immunogen Type: Synthetic peptide
• Immunogen: MFN1 antibody was raised against synthetic peptide C-NKAVQLENELEN from an internal region of human MFN1 (NP_284941.2). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Elephant, Dog, Horse, Rabbit (100%); Gorilla, Mouse, Rat, Bovine (92%); Bat, Platypus (83%).
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-MFN1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-MFN1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Related Product Information for anti-MFN1 antibody

Mitofusin 1 is an integral mitochondrial membrane protein that is required on adjacent mitochondria to mediate fusion thereby contributing to the dynamic balance between fusion and fission that determine mitochondria morphology.

NCBI and Uniprot Product Information

• NCBI GI #: 45269137
• NCBI GeneID: 55669
• NCBI Accession #: NP_284941.2
• NCBI GenBank Nucleotide #: NM_033540.2
• UniProt Accession #: Q8IWA4; O15323; O60639; Q9BZB5; Q9NWQ2; B2RAR1; D3DNR6
• Molecular Weight: 71,401 Da
• NCBI Official Full Name: mitofusin-1
• NCBI Official Synonym Full Names: mitofusin 1
• NCBI Official Symbol: MFN1
• NCBI Official Synonym Symbols: hfzo1; hfzo2
• NCBI Protein Information: mitofusin-1; fzo homolog; transmembrane GTPase MFN1; putative transmembrane GTPase; mitochondrial transmembrane GTPase FZO-2; mitochondrial transmembrane GTPase Fzo-1
• UniProt Protein Name: Mitofusin-1
• Protein Family: Mitofusin
• UniProt Gene Name: MFN1
• UniProt Entry Name: MFN1_HUMAN

NCBI Description

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]

Uniprot Description

MFN1: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Belongs to the mitofusin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Hydrolase; Mitochondrial; EC 3.6.5.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.33

Cellular Component: mitochondrial outer membrane; integral to membrane

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: mitochondrial fusion; metabolic process