Rabbit MFN1 Polyclonal Antibody | anti-MFN1 antibody

MFN1 Polyclonal Antibody

Cat. Num. AAA2527148

• Gene Names: MFN1; hfzo1; hfzo2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: MFN1; Polyclonal Antibody; MFN1 Polyclonal Antibody; hfzo1; hfzo2; anti-MFN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.2mg/mL (varies by lot)
• Sequence Length: 741

• Applicable Applications for anti-MFN1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human MFN1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using MFN1 Polyclonal Antibody at dilution 1:60)

Related Product Information for anti-MFN1 antibody

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks

NCBI and Uniprot Product Information

• NCBI GI #: 45269137
• NCBI GeneID: 55669
• NCBI Accession #: NP_284941.2
• NCBI GenBank Nucleotide #: NM_033540.2
• Molecular Weight: 71,401 Da
• NCBI Official Full Name: mitofusin-1
• NCBI Official Synonym Full Names: mitofusin 1
• NCBI Official Symbol: MFN1
• NCBI Official Synonym Symbols: hfzo1; hfzo2
• NCBI Protein Information: mitofusin-1; fzo homolog; mitochondrial transmembrane GTPase FZO-2; mitochondrial transmembrane GTPase Fzo-1; putative transmembrane GTPase; transmembrane GTPase MFN1
• UniProt Protein Name: Mitofusin-1
• Protein Family: Mitofusin
• UniProt Gene Name: MFN1
• UniProt Entry Name: MFN1_HUMAN

NCBI Description

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]

Uniprot Description

MFN1: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Belongs to the mitofusin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.6.5.-; Hydrolase; Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 3q26.33

Cellular Component: mitochondrial outer membrane; integral to membrane

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: mitochondrial fusion; metabolic process