Rabbit MEGF10 Polyclonal Antibody | anti-MEGF10 antibody

Anti-MEGF10 Antibody

Cat. Num. AAA8291639

• Gene Names: MEGF10; EMARDD
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by immunogen affinity chromatography
• Synonyms: MEGF10; Polyclonal Antibody; Anti-MEGF10 Antibody; KIAA1780; Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10; anti-MEGF10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of MEGF10 protein.
• Purity/Purification: Purified by immunogen affinity chromatography
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 567

• Applicable Applications for anti-MEGF10 antibody: Western Blot (WB)
• Application Notes: WB: 1/500 - 1/2000
• Immunogen: Recombinant full length protein of human MEGF10
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of MEGF10 expression in HT29 (A), MCF7 (B), mouse liver (C), rat brain (D) whole cell lysates.)

Related Product Information for anti-MEGF10 antibody

Rabbit polyclonal antibody to MEGF10

NCBI and Uniprot Product Information

• NCBI GI #: 375065830
• NCBI GeneID: 84466
• NCBI Accession #: NP_001243474.1
• NCBI GenBank Nucleotide #: NM_001256545.1
• UniProt Accession #: Q96KG7; Q68DE5; Q8WUL3
• Molecular Weight: 60,797 Da
• NCBI Official Full Name: multiple epidermal growth factor-like domains protein 10 isoform a
• NCBI Official Synonym Full Names: multiple EGF like domains 10
• NCBI Official Symbol: MEGF10
• NCBI Official Synonym Symbols: EMARDD
• NCBI Protein Information: multiple epidermal growth factor-like domains protein 10
• UniProt Protein Name: Multiple epidermal growth factor-like domains protein 10
• Protein Family: Multiple epidermal growth factor-like domains protein
• UniProt Gene Name: MEGF10
• UniProt Synonym Gene Names: Multiple EGF-like domains protein 10Curated

NCBI Description

This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977).