Rabbit anti-Human MDA5 Polyclonal Antibody | anti-mda5 antibody

MDA5, CT (IFIH1, Interferon-induced Helicase C Domain-containing Protein 1, Clinically Amyopathic Dermatomyositis Autoantigen 140kD, CADM-140 Autoantigen, Helicase with 2 CARD Domains, Helicard, Interferon-induced with Helicase C Domain Protein 1, Melanom

Cat. Num. AAA646633

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: MDA5; Polyclonal Antibody; CT (IFIH1; Interferon-induced Helicase C Domain-containing Protein 1; Clinically Amyopathic Dermatomyositis Autoantigen 140kD; CADM-140 Autoantigen; Helicase with 2 CARD Domains; Helicard; Interferon-induced with Helicase C Domain Protein 1; Melanom; Anti -MDA5; anti-mda5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human MDA5. Species sequence homology: Mouse.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-mda5 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 4ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 16aa from near the C-terminal of human MDA5 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Pancreas (formalin-fixed, paraffin-embedded) stained with IFIH1 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(Mouse small intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Mouse kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Mouse pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-mda5 antibody

The melanoma differentiation-associated protein 5 (MDA5) recognizes double stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal Caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kappaB.

Product Categories/Family for anti-mda5 antibody

Antibodies; Abs to DEAD Box Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 304434770
• NCBI GeneID: 100499612
• NCBI Accession #: NP_001182108.1
• NCBI GenBank Nucleotide #: NM_001195179.1
• NCBI Official Full Name: melanoma differentiation associated gene 5
• NCBI Official Symbol: mda5
• NCBI Protein Information: melanoma differentiation associated gene 5