Rabbit MCHR1 Polyclonal Antibody | anti-MCHR1 antibody

Rabbit Polyclonal to Human MCHR1

Cat. Num. AAA244093

• Gene Names: MCHR1; SLC1; GPR24; MCH1R; SLC-1; MCH-1R
• Reactivity: Chimpanzee, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: MCHR1; Polyclonal Antibody; Rabbit Polyclonal to Human MCHR1; Anti-MCHR1 Antibody (N-Terminus) IHC-plus; G-protein coupled receptor 24; G protein-coupled receptor 24; GPR24; MCH-1R; MCH receptor 1; MCH-R1; MCH1R; Somatostatin-like receptor 1; MCH 1 receptor; MCHR; SLC-1; MCHR-1; SLC1; Human MCHR1; anti-MCHR1 antibody

• Host: Rabbit
• Reactivity: Chimpanzee, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human MCHR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 422

• Applicable Applications for anti-MCHR1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (22 - 44 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human MCHR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee (100%); Gibbon (95%); Monkey, Rabbit (84%).
• Immunogen Type: Synthetic peptide
• Immunogen: MCHR1 antibody was raised against synthetic 19 amino acid peptide from N-terminal extracellular domain of human MCHR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee (100%); Gibbon (95%); Monkey, Rabbit (84%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-MCHR1 antibody IHC of human Soft Tissue, Liposarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-MCHR1 antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-MCHR1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-MCHR1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-MCHR1 antibody

MCHR1 is a Melanin-Concentrating Hormone Receptor that binds MCH to regulate nutritional homeostasis, including feeding and body adiposity. The receptor also functions in sensory perception and integration of smell and gustatory inputs, as well as in emotion and memory.

Product Categories/Family for anti-MCHR1 antibody

Family: GPCR; Subfamily: Melanin-concentrating hormone receptor

NCBI and Uniprot Product Information

• NCBI GI #: 88758590
• NCBI GeneID: 2847
• NCBI Accession #: NP_005288.3
• NCBI GenBank Nucleotide #: NM_005297.3
• UniProt Accession #: Q99705; Q5R3J1; Q96S47; Q9BV08; B2RBX6
• Molecular Weight: 45,963 Da
• NCBI Official Full Name: melanin-concentrating hormone receptor 1
• NCBI Official Synonym Full Names: melanin-concentrating hormone receptor 1
• NCBI Official Symbol: MCHR1
• NCBI Official Synonym Symbols: SLC1; GPR24; MCH1R; SLC-1; MCH-1R
• NCBI Protein Information: melanin-concentrating hormone receptor 1; MCH receptor 1; G protein-coupled receptor 24; somatostatin receptor-like protein
• UniProt Protein Name: Melanin-concentrating hormone receptor 1
• Protein Family: Melanin-concentrating hormone receptor
• UniProt Gene Name: MCHR1
• UniProt Synonym Gene Names: GPR24; SLC1; MCH receptor 1; MCH-R1; MCHR-1; MCH1R; MCHR
• UniProt Entry Name: MCHR1_HUMAN

NCBI Description

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

Uniprot Description

MCHR1: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein C-terminus binding; neuropeptide receptor activity; hormone binding; melanin-concentrating hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; neuropeptide signaling pathway; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of calcium ion transport