Rabbit anti-Human MC5R Polyclonal Antibody | anti-MC5R antibody

MC5R, CT (MC5R, Melanocortin receptor 5, MC-2) (FITC)

Cat. Num. AAA6319488

• Gene Names: MC5R; MC2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MC5R; Polyclonal Antibody; CT (MC5R; Melanocortin receptor 5; MC-2) (FITC); MC-2; anti-MC5R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-MC5R antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: MC5R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-308 amino acids from the C-terminal region of human MC5R.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MC5R Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MC5R antibody detected the MC5R protein (arrow).)

Related Product Information for anti-MC5R antibody

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.

Product Categories/Family for anti-MC5R antibody

Antibodies; Receptors

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009): Frandberg, P.A., et al. Biochem. Biophys. Res. Commun. 236(2):489-492(1997).

NCBI and Uniprot Product Information

• NCBI GI #: 5174535
• NCBI GeneID: 4161
• NCBI Accession #: NP_005904.1
• NCBI GenBank Nucleotide #: NM_005913.2
• UniProt Accession #: P33032; Q502V1; B0YJ34
• Molecular Weight: 36,601 Da
• NCBI Official Full Name: melanocortin receptor 5
• NCBI Official Synonym Full Names: melanocortin 5 receptor
• NCBI Official Symbol: MC5R
• NCBI Official Synonym Symbols: MC2
• NCBI Protein Information: melanocortin receptor 5; melanocortin-5 receptor
• UniProt Protein Name: Melanocortin receptor 5
• Protein Family: Melanocortin receptor
• UniProt Gene Name: MC5R
• UniProt Synonym Gene Names: MC5-R
• UniProt Entry Name: MC5R_HUMAN

NCBI Description

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

Uniprot Description

MC5R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; melanocortin receptor activity; hormone binding

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cAMP biosynthetic process