Rabbit anti-Human MAVS Polyclonal Antibody | anti-MAVS antibody

MAVS, CT (MAVS, IPS1, KIAA1271, VISA, Mitochondrial antiviral-signaling protein, CARD adapter inducing interferon beta, Interferon beta promoter stimulator protein 1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter) (MaxLight

Cat. Num. AAA6319226

• Gene Names: MAVS; IPS1; VISA; IPS-1; CARDIF
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: MAVS; Polyclonal Antibody; CT (MAVS; IPS1; KIAA1271; VISA; Mitochondrial antiviral-signaling protein; CARD adapter inducing interferon beta; Interferon beta promoter stimulator protein 1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter) (MaxLight; mitochondrial antiviral-signaling protein; Virus-induced-signaling adapter; anti-MAVS antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MAVS.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-MAVS antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 477-505 in the C-terminal region of human MAVS. Swiss/UniProt Accession: Q7Z434
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in Hela cell line lysates (35ug/lane) usingMBS6007995. This demonstrates that MBS6007995 detected the MAVS protein (arrow).)

Related Product Information for anti-MAVS antibody

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).

Product Categories/Family for anti-MAVS antibody

Antibodies; Mitochondrial Proteins

References

1. Sebastiani, P., et al. Science (2010). In press: 2. Wang, X., et al. Cell. Mol. Immunol. 7(5):341-348 (2010). 3. Graef, K.M., et al. J. Virol. 84(17):8433-8445 (2010). 4. Wei, C., et al. J. Immunol. 185(2):1158-1168 (2010). 5. Onoguchi, K., et al. PLoS Pathog. 6 (7), E1001012 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 83776598
• NCBI GeneID: 57506
• NCBI Accession #: NP_065797.2
• NCBI GenBank Nucleotide #: NM_020746.4
• UniProt Accession #: Q7Z434; Q2HWT5; Q3I0Y2; Q5T7I6; Q86VY7; Q9H1H3; Q9H4Y1; A8K6X0; B2BD33; B2BD34; F5H6C8; M1P2Z0
• Molecular Weight: 15,012 Da
• NCBI Official Full Name: mitochondrial antiviral-signaling protein isoform 1
• NCBI Official Synonym Full Names: mitochondrial antiviral signaling protein
• NCBI Official Symbol: MAVS
• NCBI Official Synonym Symbols: IPS1; VISA; IPS-1; CARDIF
• NCBI Protein Information: mitochondrial antiviral-signaling protein; IFN-B promoter stimulator 1; CARD adaptor inducing IFN-beta; virus-induced signaling adaptor; virus-induced-signaling adapter; CARD adapter inducing interferon beta; putative NF-kappa-B-activating protein 031N; i
• UniProt Protein Name: Mitochondrial antiviral-signaling protein
• Protein Family: Mitochondrial antiviral-signaling protein
• UniProt Gene Name: MAVS
• UniProt Synonym Gene Names: IPS1; KIAA1271; VISA; MAVS; Cardif; IPS-1; VISA
• UniProt Entry Name: MAVS_HUMAN

NCBI Description

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]