Western Blot (WB)
(MAVS Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MAVS antibody detected the MAVS protein (arrow).)
Rabbit anti-Human MAVS Polyclonal Antibody | anti-MAVS antibody
MAVS Antibody (C-term)
Western Blot (WB)
(MAVS Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MAVS antibody detected the MAVS protein (arrow).)
Western Blot (WB)
(MAVS Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MAVS antibody detected the MAVS protein (arrow).)
type-dependent manner by the transmembrane receptor TLR3 (MIM
603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and
RIGI (ROBO3; MIM 608630). These interactions initiate signaling
pathways that differ in their initial steps but converge in the
activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB
(IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1
(MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM
603734). Activated IRF3 and NFKB induce transcription of IFNB
(IFNB1; MIM 147640). For the TLR3 pathway, the intermediary
molecule before the pathways converge is the cytoplasmic protein
TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is
mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed
16239922]).
Wang, X., et al. Cell. Mol. Immunol. 7(5):341-348(2010)
Graef, K.M., et al. J. Virol. 84(17):8433-8445(2010)
Wei, C., et al. J. Immunol. 185(2):1158-1168(2010)
Onoguchi, K., et al. PLoS Pathog. 6 (7), E1001012 (2010) :
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
MAVS: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Present in T-cells, monocytes, epithelial cells and hepatocytes. Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; mitochondrion; mitochondrial membrane; integral to membrane
Molecular Function: signal transducer activity; protein binding; CARD domain binding; protein kinase binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; positive regulation of protein import into nucleus, translocation; positive regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-8 production; negative regulation of viral genome replication; defense response to bacterium; positive regulation of interferon-beta production; positive regulation of transcription factor import into nucleus; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of defense response to virus by host; activation of innate immune response; negative regulation of interferon type I production; defense response to virus; positive regulation of interferon-alpha production
Research Articles on MAVS
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Product Notes
The MAVS mavs (Catalog #AAA9213847) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 477-505. The MAVS Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MAVS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MAVS mavs for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAVS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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