Rabbit MATN4 Polyclonal Antibody | anti-MATN4 antibody

MATN4 Antibody

Cat. Num. AAA151538

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: MATN4 Antibody is affinity chromatography purified via peptide column.
• Synonyms: MATN4; Polyclonal Antibody; MATN4 Antibody; Matrilin-4; matrilin 4; anti-MATN4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: MATN4 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 540

• Applicable Applications for anti-MATN4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: MATN4 antibody can be used for detection of MATN4 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: MATN4 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human MATN4.
• Buffer: MATN4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: MATN4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of MATN4 in rat brain tissue lysate with MATN4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of MATN4 in mouse brain tissue with MATN4 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of MATN4 in mouse brain tissue with MATN4 antibody at 20 μg/mL.)

Related Product Information for anti-MATN4 antibody

MATN4 Antibody: Matrilin (MATNs) are a family of non-collagenous extracellular matrix proteins consisting of four known members that have been proposed to play key roles in the formation of both collagen-dependent and collagen-independent filamentous networks. Members of the matrilin family all share a structure made up of von Willebrand factor A domains, epidermal growth factor-like domains and a coiled coil alpha-helical module. MATN1 and MATN3 are expressed mainly in cartilage, while MATN2 and MATN4 occur in a wide variety of extracellular matrices such as embryonic kidney, lung, bone, cartilage and nervous system. The matrilin genes are strictly and differently regulated and their expression may serve as markers for cellular differentiation. MATN4 could serve as an odontoblast differentiation marker, e.g. in odontoblast stem cell research.

NCBI and Uniprot Product Information

• NCBI GI #: 13699834
• NCBI GeneID: 8785
• NCBI Accession #: NP_085080
• NCBI GenBank Nucleotide #: NM_030590.3
• UniProt Accession #: O95460; Q5QPU2; Q5QPU3; Q5QPU4; Q8N2M5; Q8N2M7; Q9H1F8; Q9H1F9; A6NH94; A6NKN5
• Molecular Weight: 59,588 Da
• NCBI Official Full Name: matrilin-4 isoform 2
• NCBI Official Synonym Full Names: matrilin 4
• NCBI Official Symbol: MATN4
• NCBI Protein Information: matrilin-4
• UniProt Protein Name: Matrilin-4
• Protein Family: Matrilin
• UniProt Gene Name: MATN4
• UniProt Entry Name: MATN4_HUMAN

NCBI Description

This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

MATN4: Major component of the extracellular matrix of cartilage. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: extracellular matrix organization and biogenesis; response to axon injury