Rabbit anti-Human MATN1 Polyclonal Antibody | anti-MATN1 antibody

MATN1, CT (MATN1, CMP, CRTM, Cartilage matrix protein, Matrilin-1) (APC)

Cat. Num. AAA6319189

• Gene Names: MATN1; CMP; CRTM
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MATN1; Polyclonal Antibody; CT (MATN1; CMP; CRTM; Cartilage matrix protein; Matrilin-1) (APC); Matrilin-1; anti-MATN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-MATN1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: MATN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-413 amino acids from the C-terminal region of human MATN1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(MATN1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MATN1 antibody detected the MATN1 protein (arrow).)

Immunohistochemistry (IHC)

(MATN1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MATN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-MATN1 antibody

This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias.

Product Categories/Family for anti-MATN1 antibody

Antibodies; Proteins

References

Jang, J.Y., et al. J. Dent. Res. 89(11):1203-1207(2010). Fresquet, M., et al. J. Biol. Chem. 285(44):34048-34061(2010). Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009): Chen, Z.J., et al. Zhonghua Wai Ke Za Zhi 47(17):1332-1335(2009). Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4505111
• NCBI GeneID: 4146
• NCBI Accession #: NP_002370.1
• NCBI GenBank Nucleotide #: NM_002379.3
• UniProt Accession #: P21941; Q5TBB9; B2R7E3
• Molecular Weight: 53,701 Da
• NCBI Official Full Name: cartilage matrix protein
• NCBI Official Synonym Full Names: matrilin 1, cartilage matrix protein
• NCBI Official Symbol: MATN1
• NCBI Official Synonym Symbols: CMP; CRTM
• NCBI Protein Information: cartilage matrix protein
• UniProt Protein Name: Cartilage matrix protein
• Protein Family: Cartilage matrix protein
• UniProt Gene Name: MATN1
• UniProt Synonym Gene Names: CMP; CRTM
• UniProt Entry Name: MATN1_HUMAN

NCBI Description

This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. [provided by RefSeq, Jul 2008]

Uniprot Description

MATN1: Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent

Biological Process: extracellular matrix organization and biogenesis; protein complex assembly; regulation of bone mineralization