Rabbit anti-Mouse Matk Polyclonal Antibody | anti-Matk antibody

Matk, CT (Matk, Ctk, Ntk, Megakaryocyte-associated tyrosine-protein kinase, Protein kinase NTK, Tyrosine-protein kinase CTK) (Biotin)

Cat. Num. AAA6319179

• Gene Names: Matk; CHK; HYL; Ntk
• Reactivity: Mouse
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Matk; Polyclonal Antibody; CT (Matk; Ctk; Ntk; Megakaryocyte-associated tyrosine-protein kinase; Protein kinase NTK; Tyrosine-protein kinase CTK) (Biotin); Tyrosine-protein kinase CTK; anti-Matk antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-Matk antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: Mouse Matk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-505 amino acids from the C-terminal region of Mouse Matk.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Mouse Matk Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Matk antibody detected the Matk protein (arrow).)

Immunohistochemistry (IHC)

(Mouse Matk Antibody (C-term) (AP14271b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Matk Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-Matk antibody

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Product Categories/Family for anti-Matk antibody

Antibodies; Protein Kinases

References

Lee, B.C., et al. Blood 108(3):904-907(2006). Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000). Puttagunta, R., et al. Genome Res. 10(9):1369-1380(2000). Samokhvalov, I., et al. Biochem. Mol. Biol. Int. 43(1):115-122(1997). Kozak, C.A., et al. Mamm. Genome 7(2):164-165(1996).

NCBI and Uniprot Product Information

• NCBI GI #: 6754646
• NCBI GeneID: 17179
• NCBI Accession #: NP_034898.1
• NCBI GenBank Nucleotide #: NM_010768.1
• UniProt Accession #: P41242; Q6LE90
• Molecular Weight: 56,056 Da
• NCBI Official Full Name: megakaryocyte-associated tyrosine-protein kinase
• NCBI Official Synonym Full Names: megakaryocyte-associated tyrosine kinase
• NCBI Official Symbol: Matk
• NCBI Official Synonym Symbols: CHK; HYL; Ntk
• NCBI Protein Information: megakaryocyte-associated tyrosine-protein kinase; protein kinase NTK; Csk homologous kinase; tyrosine-protein kinase CTK
• UniProt Protein Name: Megakaryocyte-associated tyrosine-protein kinase
• Protein Family: Maturase
• UniProt Gene Name: Matk
• UniProt Synonym Gene Names: Ctk; Ntk
• UniProt Entry Name: MATK_MOUSE

Uniprot Description

CTK: a non-receptor tyrosine kinase. Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Expressed in cancerous but not normal breast tissue; interacts with activated ERBB2 receptor and is likely to inhibit proliferation.

Protein type: EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Csk family

Cellular Component: extrinsic to internal side of plasma membrane; membrane; cytoplasm

Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; ATP binding; receptor binding; protein kinase activity

Biological Process: cell migration; innate immune response; morphogenesis of an epithelium; cell differentiation; protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation