Immunohistochemistry (IHC)
(Anti-MARK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit MARK1 / MARK Polyclonal Antibody | anti-MARK1 antibody
Rabbit Polyclonal to Human MARK1 / MARK
Gene Names
MARK1; MARK; Par1c; Par-1c
Reactivity
Gibbon, Horse, Human, Monkey, RabbitPredicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
MARK1 / MARK; Polyclonal Antibody; Rabbit Polyclonal to Human MARK1 / MARK; Anti-MARK1 / MARK Antibody (N-Terminus) IHC-plus; MARK1; KIAA1477; Par1c; PAR1 homolog c; MARK; Par-1c; Human MARK1; anti-MARK1 antibody
Host
Rabbit
Reactivity
Gibbon, Horse, Human, Monkey, Rabbit
Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)
Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human MARK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
795
Applicable Applications for anti-MARK1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from N-terminus of human MARK1. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Horse, Rabbit (100%); Dog, Bovine, Panda (95%); Rat, Hamster, Elephant, Platypus (89%).
Immunogen Type
Synthetic peptide
Immunogen
MARK1 / MARK antibody was raised against synthetic 19 amino acid peptide from N-terminus of human MARK1. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Horse, Rabbit (100%); Dog, Bovine, Panda (95%); Rat, Hamster, Elephant, Platypus (89%); Mouse, Opossum, Turkey, Chicken, Lizard (84%).
Antigen Modification
N-Terminus
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Immunohistochemistry (IHC)
(Anti-MARK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-MARK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-MARK1 antibody
MARK1, a MARK type protein kinase, has been shown to phosphorylate the microtubule-associated proteins tau, MAP2, and MAP4 on their microtubule-binding domain causing their dissociation from microtubules.
Product Categories/Family for anti-MARK1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
84,911 Da
NCBI Official Full Name
serine/threonine-protein kinase MARK1 isoform 2
NCBI Official Synonym Full Names
MAP/microtubule affinity-regulating kinase 1
NCBI Official Symbol
MARK1
NCBI Official Synonym Symbols
MARK; Par1c; Par-1c
NCBI Protein Information
serine/threonine-protein kinase MARK1; PAR1 homolog c
UniProt Protein Name
Serine/threonine-protein kinase MARK1
Protein Family
UniProt Gene Name
MARK1
UniProt Synonym Gene Names
Par-1c; Par1c
UniProt Entry Name
MARK1_HUMAN
Uniprot Description
MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue.
Protein type: EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; MARK subfamily
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: microtubule cytoskeleton; cytoskeleton; cytoplasm; plasma membrane
Molecular Function: protein serine/threonine kinase activity; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; tau-protein kinase activity; magnesium ion binding; ATP binding
Biological Process: Wnt receptor signaling pathway; neuron migration; cytoskeleton organization and biogenesis; protein amino acid phosphorylation
Research Articles on MARK1
Similar Products
Product Notes
The MARK1 mark1 (Catalog #AAA241512) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human MARK1 / MARK reacts with Gibbon, Horse, Human, Monkey, Rabbit Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's MARK1 / MARK can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (2.5 ug/ml) Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the MARK1 mark1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MARK1 / MARK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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