Rabbit anti-Human ARHGAP45 Polyclonal Antibody | anti-ARHGAP45 antibody

ARHGAP45 Antibody

Cat. Num. AAA9430768

• Gene Names: ARHGAP45; HA-1; HMHA1; HLA-HA1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ARHGAP45; Polyclonal Antibody; ARHGAP45 Antibody; HA-1; HMHA1; HLA-HA1; anti-ARHGAP45 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total ARHGAP45 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.5 mg/mL (varies by lot)
• Sequence Length: 1152

• Applicable Applications for anti-ARHGAP45 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:10-50
• Immunogen: Synthetic peptide of human ARHGAP45
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 47786(ARHGAP45 Antibody) at dilution 1/20.(Original magnification: 200))

Related Product Information for anti-ARHGAP45 antibody

Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Product Categories/Family for anti-ARHGAP45 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 385251392
• NCBI GeneID: 23526
• NCBI Accession #: NP_001245257.1
• NCBI GenBank Nucleotide #: NM_001258328.2
• UniProt Accession #: Q92619; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24; B4DTS4; F6QP70
• Molecular Weight: 126,497 Da
• NCBI Official Full Name: rho GTPase-activating protein 45 isoform 2
• NCBI Official Synonym Full Names: Rho GTPase activating protein 45
• NCBI Official Symbol: ARHGAP45
• NCBI Official Synonym Symbols: HA-1; HMHA1; HLA-HA1
• NCBI Protein Information: rho GTPase-activating protein 45
• UniProt Protein Name: Rho GTPase-activating protein 45
• UniProt Gene Name: ARHGAP45
• UniProt Synonym Gene Names: HMHA1ImportedManual assertion inferred from database entriesiHGNC:17102; KIAA0223ImportedManual assertion inferred from database entriesiHGNC:17102; mHag HA-1

Uniprot Description

Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.