Rabbit anti-Human MALT1 Polyclonal Antibody | anti-MALT1 antibody

MALT1 (Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1, MALT Lymphoma-associated Translocation, Paracaspase, MLT), DKFZp434L132) (HRP)

Cat. Num. AAA6384668

• Gene Names: MALT1; MLT; MLT1; DKFZp434L132
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MALT1; Polyclonal Antibody; MALT1 (Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1; MALT Lymphoma-associated Translocation; Paracaspase; MLT); DKFZp434L132) (HRP); anti-MALT1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MALT1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-MALT1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human MALT1, aa1-813 (NP_776216.1).
• Immunogen Sequence: MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MALT1 expression in transfected 293T cell line by MALT1 polyclonal antibody. Lane 1: MALT1 transfected lysate (91.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-MALT1 antibody

MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma. MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10-activate NF-kappaB. MALT1 is thought to play an important role in NF-kappaB signaling by enchancing NF-kappaB activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK activation in vitro through facilitatiing the ubiquitination of NEMO by the ubiquitin-conjugating enzyme UBC13. Four recurrent chromosomal translocations have been described in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid issue (MALT) type. Two of them,t(14;18)(q32;q21) and t(11;18)(q21;q21), are found in 30% to 50% of extranodal MALT lymphomas. The first translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in the deregulation of MALT1 expression, whereas the second translocation generates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1). The other two much rarer translocations, t(1;14)(p22;q32)and t(1;2)(p22;p12), target Bcl10 gene on the short arm of chromosome 1. Translocations involving Bcl10 and MALT1 may lead to elevated NF-kappaB activity in MALT B-cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms (a and b) have been described for the MALT1 gene. Human MALT1 isoform a is an aa protein of 824aa, and human MALT1 isoform b is an aa protein of 813aa.

Product Categories/Family for anti-MALT1 antibody

Antibodies; Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 27886566
• NCBI GeneID: 10892
• NCBI Accession #: NP_776216.1
• NCBI GenBank Nucleotide #: NM_173844
• UniProt Accession #: Q9UDY8; Q9NTB7; Q9ULX4
• Molecular Weight: 92,272 Da
• NCBI Official Full Name: mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform b
• NCBI Official Synonym Full Names: mucosa associated lymphoid tissue lymphoma translocation gene 1
• NCBI Official Symbol: MALT1
• NCBI Official Synonym Symbols: MLT; MLT1; DKFZp434L132
• NCBI Protein Information: mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; OTTHUMP00000163647; OTTHUMP00000163648; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation
• UniProt Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1
• Protein Family: Mucosa-associated lymphoid tissue lymphoma translocation protein
• UniProt Gene Name: MALT1
• UniProt Synonym Gene Names: MLT
• UniProt Entry Name: MALT1_HUMAN

Uniprot Description

MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; Ligase; Adaptor/scaffold; EC 3.4.22.-; Protease; Ubiquitin conjugating system; Apoptosis

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: CBM complex; protein complex; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; nucleus; cytosol

Molecular Function: peptidase activity; protein binding; signal transducer activity; protein self-association; protease binding; cysteine-type endopeptidase activity; ubiquitin-protein ligase activity; kinase activator activity

Biological Process: response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; nuclear export; activation of NF-kappaB-inducing kinase; positive regulation of T cell cytokine production; protein ubiquitination; defense response; proteolysis; T cell receptor signaling pathway; protein oligomerization; activation of NF-kappaB transcription factor; T cell proliferation; regulation of apoptosis; B-1 B cell differentiation; positive regulation of protein ubiquitination; response to molecule of bacterial origin; regulation of T cell receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of T cell activation; negative regulation of apoptosis

Disease: Immunodeficiency 12