Western Blot (WB)
(Fig: 1 Western blot analysis of MALT1/Paracaspase expression using at 1: 2000. HEK293N cells transiently transfected with control (empty) plasmid (Ctl-) or human full-length MALT1 (Ctl+) were used as negative or positive controls, respectively. Freshly isolated human polymorphonuclear neutrophils (PMN) and resting B-cells were negative. MALT1 expression was detected in SKW64, Ramos, and BJAB B-cell lymphoma lines, and 3 out of 6 B-cell chronic lymphocytic luekemia (CLL) patients.)
Rabbit MALT-1 Polyclonal Antibody | anti-MALT1 antibody
Polyclonal Antibody to MALT-1 (Paracaspase)
Predicted: Mouse
Predicted: Mouse
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Western Blot (WB)
(Fig: 1 Western blot analysis of MALT1/Paracaspase expression using at 1: 2000. HEK293N cells transiently transfected with control (empty) plasmid (Ctl-) or human full-length MALT1 (Ctl+) were used as negative or positive controls, respectively. Freshly isolated human polymorphonuclear neutrophils (PMN) and resting B-cells were negative. MALT1 expression was detected in SKW64, Ramos, and BJAB B-cell lymphoma lines, and 3 out of 6 B-cell chronic lymphocytic luekemia (CLL) patients.)
Western Blot (WB)
(Fig: 1 Western blot analysis of MALT1/Paracaspase expression using at 1: 2000. HEK293N cells transiently transfected with control (empty) plasmid (Ctl-) or human full-length MALT1 (Ctl+) were used as negative or positive controls, respectively. Freshly isolated human polymorphonuclear neutrophils (PMN) and resting B-cells were negative. MALT1 expression was detected in SKW64, Ramos, and BJAB B-cell lymphoma lines, and 3 out of 6 B-cell chronic lymphocytic luekemia (CLL) patients.)
Immunohistochemistry (IHC)
(Fig: 2 Immunohistochemical analysis of MALT1/Paracaspase expression in formalin-fixed human reactive lymph node using at 1: 2000. A. Low magnification. A1-3, high magnification from A: A1, mantle zone. A2, germinal center. A3. marginal zone. Hematoxylin-eosin counterstain.)
Immunohistochemistry (IHC)
(Fig: 2 Immunohistochemical analysis of MALT1/Paracaspase expression in formalin-fixed human reactive lymph node using at 1: 2000. A. Low magnification. A1-3, high magnification from A: A1, mantle zone. A2, germinal center. A3. marginal zone. Hematoxylin-eosin counterstain.)
NCBI and Uniprot Product Information
NCBI Description
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 18q21.32
Cellular Component: cytoplasm; cytosol; nucleolus; nucleus; plasma membrane; protein complex
Molecular Function: kinase activator activity; peptidase activity; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of T cell activation; positive regulation of T cell cytokine production; protein oligomerization; proteolysis; regulation of apoptosis; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway
Disease: Immunodeficiency 12
Research Articles on MALT1
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Product Notes
The MALT1 malt1 (Catalog #AAA668709) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to MALT-1 (Paracaspase) reacts with Human Predicted: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MALT-1 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB). WB: 1: 1000-1: 2000 IHC (paraffin): 1: 1000-1: 5000 IP: 1: 50-1: 200. Researchers should empirically determine the suitability of the MALT1 malt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MALT-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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