Rabbit MAGG1 Polyclonal Antibody | anti-MAGG1 antibody

MAGG1 Antibody

Cat. Num. AAA9602901

• Gene Names: NSMCE3; HCA4; LICS; NSE3; NDNL2; MAGEG1; MAGEL3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: MAGG1; Polyclonal Antibody; MAGG1 Antibody; HCA4; hepatocellular carcinoma-associated protein 4; hepatocellular carcinoma-associated protein HCA4; MAGE-G1 antigen; MAGEG1; MAGEL3; melanoma antigen; family G; 1; melanoma-associated antigen G1; necdin-like 2; necdin-like gene 2; necdin-like protein 2; NSE3; NSMCE3; anti-MAGG1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MAGG1 antibody detects endogenous levels of total MAGG1
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 304

• Applicable Applications for anti-MAGG1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human MAGG1
• Subcellular Location: Cytoplasmic and Nuclear
• Tissue Specificity: Ubiquitous.
• Predicted Cross Reactivity: Bovine, Horse, Rabbit
• Similarity: Bovine (91%), Horse (91%), Rabbit (82%)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of MAGG1 using 293 whole cell lysates)

Western Blot (WB)

(Western blot analysis of extracts from various samples, using MAGG1 Antibody. Lane 1: mouse brain treated with blocking peptide. Lane 2: mouse brain; Lane 3: rat brain; Lane 4: Hepg2; )

Related Product Information for anti-MAGG1 antibody

Function: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).
Subunit Structure: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer (PubMed:18086888). Interacts with PJA1 (PubMed:20864041). Interacts with E2F1 (via C-terminus) (By similarity). Interacts with NGFR (via C-terminus) (By similarity). Interacts with NSMCE1 (PubMed:18086888, PubMed:21364888, PubMed:20864041, PubMed:27427983). Interacts with NSMCE4 (PubMed:20864041, PubMed:27427983). Interacts with SMC6 (PubMed:18086888). Interacts with EID3 (PubMed:21364888).

NCBI and Uniprot Product Information

• NCBI GI #: 20162572
• NCBI GeneID: 56160
• NCBI Accession #: NP_619649.1
• NCBI GenBank Nucleotide #: NM_138704.3
• UniProt Accession #: Q96MG7; Q8IW16; Q8TEI6; Q9H214
• Molecular Weight: Observed: 34 kDa; Predicted: 35 kDa
• NCBI Official Full Name: non-structural maintenance of chromosomes element 3 homolog
• NCBI Official Synonym Full Names: NSE3 homolog, SMC5-SMC6 complex component
• NCBI Official Symbol: NSMCE3
• NCBI Official Synonym Symbols: HCA4; LICS; NSE3; NDNL2; MAGEG1; MAGEL3
• NCBI Protein Information: non-structural maintenance of chromosomes element 3 homolog
• UniProt Protein Name: Non-structural maintenance of chromosomes element 3 homolog
• UniProt Gene Name: NSMCE3
• UniProt Synonym Gene Names: Non-SMC element 3 homolog

NCBI Description

The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]

Uniprot Description

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest ().