Rabbit anti-Human, Mouse MAGEA6 Polyclonal Antibody | anti-MAGEA6 antibody

MAGEA6 Rabbit Polyclonal

Cat. Num. AAA7601172

• Gene Names: MAGEA6; CT1.6; MAGE6; MAGE3B; MAGE-3b
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MAGEA6; Polyclonal Antibody; MAGEA6 Rabbit Polyclonal; anti-MAGEA6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 314

• Applicable Applications for anti-MAGEA6 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Melanoma antigen family A, 6
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer using MBS7601172 (MAGEA6 antibody) at dilution of 1:50)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7601172 (MAGEA6 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 29029627
• NCBI GeneID: 4105
• NCBI Accession #: NP_787064.1
• NCBI GenBank Nucleotide #: NM_175868.2
• Molecular Weight: 34,891 Da
• NCBI Official Full Name: melanoma-associated antigen 6
• NCBI Official Synonym Full Names: MAGE family member A6
• NCBI Official Symbol: MAGEA6
• NCBI Official Synonym Symbols: CT1.6; MAGE6; MAGE3B; MAGE-3b
• NCBI Protein Information: melanoma-associated antigen 6
• UniProt Protein Name: Melanoma-associated antigen 6
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA6
• UniProt Synonym Gene Names: MAGE6; CT1.6
• UniProt Entry Name: MAGA6_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

MAGE-A6: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28

Molecular Function: protein binding