Western Blot (WB)
(Mouse Hoxa2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Hoxa2 antibody detected the Hoxa2 protein (arrow).)
Rabbit anti-Mouse Hoxa2 Polyclonal Antibody | anti-HOXA2 antibody
Hoxa2, ID (Hoxa2, Hox-1.11, Hoxa-2, Homeobox protein Hox-A2, Homeobox protein Hox-1.11)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(Mouse Hoxa2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Hoxa2 antibody detected the Hoxa2 protein (arrow).)
Western Blot (WB)
(Mouse Hoxa2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Hoxa2 antibody detected the Hoxa2 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]
Uniprot Description
HOXA2: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA2 are a cause of microtia hearing impairment and cleft palate (MHICP). Microtia is a congenital deformity of the outer ear and occurs in approximately one in 8'000-10'000 births. It is characterized by a small, abnormally shaped outer ear. It can be unilateral or bilateral. Syndromic forms of microtia occur in conjunction with other abnormalities. The most common associated malformations is the cleft palate, a congenital fissure of the soft and/or hard palate due to faulty fusion. Defects in HOXA2 are a cause of autosomal- recessive bilateral microtia, mixed symmetrical severe to profound hearing impairment and partial cleft palate. Belongs to the Antp homeobox family. Proboscipedia subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: nucleoplasm
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: transcription, DNA-dependent; motor axon guidance; embryonic viscerocranium morphogenesis; middle ear morphogenesis; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; osteoblast development; anterior/posterior pattern formation; segment specification; negative regulation of neuron differentiation; dorsal/ventral pattern formation; rhombomere 2 development; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; rhombomere 3 morphogenesis; brain segmentation
Disease: Microtia, Hearing Impairment, And Cleft Palate
Research Articles on HOXA2
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Product Notes
The HOXA2 hoxa2 (Catalog #AAA6000667) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Hoxa2, ID (Hoxa2, Hox-1.11, Hoxa-2, Homeobox protein Hox-A2, Homeobox protein Hox-1.11) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Hoxa2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the HOXA2 hoxa2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hoxa2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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