Western Blot (WB)
((0.5ug/ml) staining of Human Heart (A) and Placenta (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat lysyl oxidase Polyclonal Antibody | anti-LOX antibody
Goat Anti-lysyl oxidase Antibody
Tested: Human
Expected from sequence similarity: Human, Pig
Tested: Human
Expected from sequence similarity: Human, Pig
Peptide ELISA: Antibody detection limit dilution 1:128000.
Western Blot (WB)
((0.5ug/ml) staining of Human Heart (A) and Placenta (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((0.5ug/ml) staining of Human Heart (A) and Placenta (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
Uniprot Description
LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.
Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.4.3.13
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: extracellular region
Molecular Function: protein binding
Biological Process: extracellular matrix organization and biogenesis; protein modification process
Disease: Cutis Laxa, Autosomal Recessive, Type Ia
Research Articles on LOX
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Product Notes
The LOX lox (Catalog #AAA423672) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Anti-lysyl oxidase Antibody reacts with Human, Pig Tested: Human Expected from sequence similarity: Human, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's lysyl oxidase can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Western Blot: Approx 30-33kDa band observed in Human Heart and Human Placenta lysates (calculated MW of 46.9kDa according to NP_002308.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Kuivaniemi et al, J Biol Ch Peptide ELISA: Antibody detection limit dilution 1:128000. Researchers should empirically determine the suitability of the LOX lox for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: STAYRADVRD YDHR. It is sometimes possible for the material contained within the vial of "lysyl oxidase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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