Western Blot (WB)
(Anti-LTK antibody, MBS176084, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human LTK,33.1KD(162aa tag+ N729-S864)Lane 1: Recombinant Human LTK Protein 10ngLane 2: Recombinant Human LTK Protein 5ngLane 3: Recombinant Human LTK Protein 2.5ngLane 4: Recombinant Human LTK Protein 1.25ng )
Rabbit anti-Human LTK Polyclonal Antibody | anti-LTK antibody
Anti-LTK antibody
Western Blot (WB)
(Anti-LTK antibody, MBS176084, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human LTK,33.1KD(162aa tag+ N729-S864)Lane 1: Recombinant Human LTK Protein 10ngLane 2: Recombinant Human LTK Protein 5ngLane 3: Recombinant Human LTK Protein 2.5ngLane 4: Recombinant Human LTK Protein 1.25ng )
Western Blot (WB)
(Anti-LTK antibody, MBS176084, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human LTK,33.1KD(162aa tag+ N729-S864)Lane 1: Recombinant Human LTK Protein 10ngLane 2: Recombinant Human LTK Protein 5ngLane 3: Recombinant Human LTK Protein 2.5ngLane 4: Recombinant Human LTK Protein 1.25ng )
Background: LTK(Leukocyte Tyrosine Kinase), also known as TYK1, is an enzyme that in humans is encoded by the LTK gene. The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases(RTKs) whose ligand is unknown. Toyoshima et al.(1993) cloned a set of cDNAs representing differently spliced human LTK mRNAs. Liao et al.(1996) found that the mouse Ltk gene is closely linked to the Tyro3 gene which maps to mouse chromosome 2. Thus, the LTK gene produces not only the putative receptor tyrosine kinase for an unknown ligand but also multiple protein products that may have different functions.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Description
LTK: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Expressed in non-hematopoietic cell lines and T- and B-cell lines. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Membrane protein, integral; TK group; Alk family
Chromosomal Location of Human Ortholog: 15q15.1-q21.1
Cellular Component: membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: cell proliferation; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; signal transduction; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Research Articles on LTK
Similar Products
Product Notes
The LTK ltk (Catalog #AAA176084) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LTK antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LTK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LTK ltk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LTK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
