Rabbit anti-Human LSM11 Polyclonal Antibody | anti-LSM11 antibody

LSM11 Antibody

Cat. Num. AAA9415149

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: LSM11; Polyclonal Antibody; LSM11 Antibody; 2210404M20Rik; FLJ38273; LSM11 homolog; U7 small nuclear RNA associated; anti-LSM11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total LSM11 protein.
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 360

• Applicable Applications for anti-LSM11 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:20-1:100
• Immunogen: Fusion protein of human LSM11
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/20.)

Related Product Information for anti-LSM11 antibody

Sm and Sm-like (LSm) proteins form donut-shaped, ubiquitously expressed heptameric complexes that are involved in various steps of RNA metabolism, including RNA-protein interactions and structural changes that are required during ribosomal subunit assembly. LSm11 is a 360 amino acid protein that localizes to the nucleus and belongs to the LSm subfamily of snRNP Sm proteins. Containing an N-terminal domain that is necessary for pre-mRNA cleavage, LSm11 functions to binds specifically to U7 snRNA and is thought to play a role in cell cycle regulation and cell growth. The gene encoding LSm11 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Product Categories/Family for anti-LSM11 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 27735089
• NCBI GeneID: 134353
• NCBI Accession #: NP_775762.1
• NCBI GenBank Nucleotide #: NM_173491.3
• UniProt Accession #: P83369; Q7Z7P0; Q8N975; A0AVQ1
• Molecular Weight: 39,500 Da
• NCBI Official Full Name: U7 snRNA-associated Sm-like protein LSm11
• NCBI Official Synonym Full Names: LSM11, U7 small nuclear RNA associated
• NCBI Official Symbol: LSM11
• NCBI Protein Information: U7 snRNA-associated Sm-like protein LSm11
• UniProt Protein Name: U7 snRNA-associated Sm-like protein LSm11
• Protein Family: U7 snRNA-associated Sm-like protein
• UniProt Gene Name: LSM11
• UniProt Entry Name: LSM11_HUMAN

Uniprot Description

LSM11: Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: nucleoplasm; nucleus; telomerase holoenzyme complex

Molecular Function: protein binding

Biological Process: histone mRNA 3'-end processing; histone mRNA metabolic process; termination of RNA polymerase II transcription