Western Blot (WB)
(LRRC8B Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LRRC8B antibody detected the LRRC8B protein (arrow).)
Rabbit anti-Human LRRC8B Polyclonal Antibody | anti-LRRC8B antibody
LRRC8B Antibody (N-term)
Western Blot (WB)
(LRRC8B Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LRRC8B antibody detected the LRRC8B protein (arrow).)
Western Blot (WB)
(LRRC8B Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LRRC8B antibody detected the LRRC8B protein (arrow).)
Immunohistochemistry (IHC)
(LRRC8B Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRRC8B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(LRRC8B Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRRC8B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Kubota, K., et al. FEBS Lett. 564 (1-2), 147-152 (2004) :
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
NCBI and Uniprot Product Information
Uniprot Description
LRRC8B: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8B constitutes a pore-forming subunit or whether it is closely associated with the pore. Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8E), possibly to form a heterohexamer
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p22.2
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding
Biological Process: ion transport
Research Articles on LRRC8B
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Product Notes
The LRRC8B lrrc8b (Catalog #AAA9212394) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 223-252. The LRRC8B Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LRRC8B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the LRRC8B lrrc8b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LRRC8B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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