Rabbit LMBRD1 Polyclonal Antibody | anti-LMBRD1 antibody

LMBRD1 Antibody

Cat. Num. AAA9409860

• Gene Names: LMBRD1; NESI; LMBD1; MAHCF; C6orf209
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: LMBRD1; Polyclonal Antibody; LMBRD1 Antibody; LMBR domain containing 1; LMBD1; nuclear export-signal interacting protein; NESI; anti-LMBRD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 540

• Applicable Applications for anti-LMBRD1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against an 18 amino acid peptide near the carboxy terminus of human LMBRD1.
• Target Name: LMBRD1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of LMBRD1 in human brain tissue lysate with LMBRD1 antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of LMBRD1 in human brain tissue with LMBRD1 antibody at 2.5 ug/mL.)

Related Product Information for anti-LMBRD1 antibody

LMBRD1, also known as NESI (nuclear export signal-interacting protein, is a lysosomal membrane protein that is thought be involved in the transport and metabolism of cobalamin. LMBRD1 was initially identified as interacting with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F (cblF).

Product Categories/Family for anti-LMBRD1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 261878497
• NCBI GeneID: 55788
• NCBI Accession #: NP_060838
• NCBI GenBank Nucleotide #: NM_018368.3
• Molecular Weight: 21,394 Da
• NCBI Official Full Name: probable lysosomal cobalamin transporter
• NCBI Official Synonym Full Names: LMBR1 domain containing 1
• NCBI Official Symbol: LMBRD1
• NCBI Official Synonym Symbols: NESI; LMBD1; MAHCF; C6orf209
• NCBI Protein Information: probable lysosomal cobalamin transporter
• UniProt Protein Name: Probable lysosomal cobalamin transporter
• UniProt Gene Name: LMBRD1
• UniProt Synonym Gene Names: C6orf209; NESI
• UniProt Entry Name: LMBD1_HUMAN

NCBI Description

This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]

Uniprot Description

LMBRD1: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAHCF). A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12. Belongs to the LIMR family. LMBRD1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: membrane; lysosomal membrane; plasma membrane; integral to membrane; clathrin-coated endocytic vesicle

Molecular Function: insulin receptor binding; cobalamin binding

Biological Process: negative regulation of glucose import; negative regulation of protein kinase B signaling cascade; vitamin metabolic process; viral reproduction; cobalamin metabolic process; negative regulation of insulin receptor signaling pathway; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria And Homocystinuria, Cblf Type