Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using Liprin alpha 1 antibody at 1:200 dilution.)
Rabbit Liprin alpha 1 Polyclonal Antibody | anti-PPFIA1 antibody
Liprin alpha 1 antibody
ICC:1:100-1:200
WB: 1:5000-1:20000
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using Liprin alpha 1 antibody at 1:200 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using Liprin alpha 1 antibody at 1:200 dilution.)
Western Blot (WB)
(Western blot analysis of 30 ug of whole cell lysate (A: JurKat) using a 5 % SDS PAGE gel and Liprin alpha 1 antibody at a dilution of 1:10000)
Western Blot (WB)
(Western blot analysis of 30 ug of whole cell lysate (A: JurKat) using a 5 % SDS PAGE gel and Liprin alpha 1 antibody at a dilution of 1:10000)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
liprin alpha 1: a ubiqutous member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Two alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: focal adhesion; cytoplasm; presynaptic active zone; cytosol
Molecular Function: signal transducer activity; protein binding
Biological Process: synaptic transmission; negative regulation of stress fiber formation; glutamate secretion; neurotransmitter secretion; cell-matrix adhesion; signal transduction
Research Articles on PPFIA1
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Product Notes
The PPFIA1 ppfia1 (Catalog #AAA837681) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Liprin alpha 1 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB). IF:1:100-1:200 ICC:1:100-1:200 WB: 1:5000-1:20000. Researchers should empirically determine the suitability of the PPFIA1 ppfia1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Liprin alpha 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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